Question 1

Which type of gene is required for cell growth and division but can cause malignant transformation when altered?

Accepted Answer

A)  Tumor suppressor gene 
B)  Proto-oncogene 
C)  Anti-tumor gene 
D)  Immunoglobulin gene 
A)  Tumor suppressor gene 
B)  Proto-oncogene 
C)  Anti-tumor gene 
D)  Immunoglobulin gene B

Question 2

What is the correct order of protein migration,starting at the cathode and moving to anode,following serum protein electrophoresis?

Accepted Answer

A)  Albumin, gamma, alpha 1, alpha 2, beta 
B)  Albumin, alpha 1, alpha 2, beta, and gamma 
C)  Gamma, beta, alpha 2, alpha 1, albumin 
D)  Beta, gamma, alpha 2, and alpha 1, albumin 
A)  Albumin, gamma, alpha 1, alpha 2, beta 
B)  Albumin, alpha 1, alpha 2, beta, and gamma 
C)  Gamma, beta, alpha 2, alpha 1, albumin 
D)  Beta, gamma, alpha 2, and alpha 1, albumin C

Question 3

A patient's immunofixation electrophoresis shows excessive amounts of free monoclonal light chains.These light chains are referred to as:

Accepted Answer

A)  Bence Jones proteins. 
B)  precipitated immunoglobulin A 
C)  albumin. 
D)  alpha-1 antitrypsin. 
A)  Bence Jones proteins. 
B)  precipitated immunoglobulin A 
C)  albumin. 
D)  alpha-1 antitrypsin. A

Question 4

Malignant plasma cells exhibiting CD38,CD56,and CD138 are found in:

Accepted Answer

A)  Waldenström macroglobulinemia. 
B)  chronic myeloid leukemia. 
C)  multiple myeloma. 
D)  monoclonal gammopathy of undetermined significance. 
A)  Waldenström macroglobulinemia. 
B)  chronic myeloid leukemia. 
C)  multiple myeloma. 
D)  monoclonal gammopathy of undetermined significance.

Question 5

Which cytogenetic abnormality is associated with an excellent prognosis in children with B-cell acute lymphoblastic leukemia (ALL)?

Accepted Answer

A)  t(12:21)(p13;q22) 
B)  t(14:18)(p13;q22) 
C)  t(9;22) 
D)  Hypodiploidy 
A)  t(12:21)(p13;q22) 
B)  t(14:18)(p13;q22) 
C)  t(9;22) 
D)  Hypodiploidy

Question 6

Which statement regarding myelogenous leukemias is true?

Accepted Answer

A)  They originate from a common colony-forming cell line. 
B)  They originate from a common myeloid precursor cell. 
C)  They originate from a common erythroid precursor cell. 
D)  They originate from a common megakaryocytic precursor cell. 
A)  They originate from a common colony-forming cell line. 
B)  They originate from a common myeloid precursor cell. 
C)  They originate from a common erythroid precursor cell. 
D)  They originate from a common megakaryocytic precursor cell.

Question 7

Which of the following is not a characteristic in the identification of lymphoma of B-cell origin?

Accepted Answer

A)  Surface immunoglobulins 
B)  Cell-surface proteins CD19 and CD20 
C)  Rearrangement of immunoglobulin genes 
D)  Presence of CD14 and CD15 
A)  Surface immunoglobulins 
B)  Cell-surface proteins CD19 and CD20 
C)  Rearrangement of immunoglobulin genes 
D)  Presence of CD14 and CD15

Question 8

Which of the following findings is a diagnostic criterion for monoclonal gammopathy of undetermined significance?

Accepted Answer

A)  Serum monoclonal protein greater than 3 g/dL 
B)  Plasma cell count lower than 10% of total cells in bone marrow 
C)  Increased calcium in the blood 
D)  Presence of CRAB features 
A)  Serum monoclonal protein greater than 3 g/dL 
B)  Plasma cell count lower than 10% of total cells in bone marrow 
C)  Increased calcium in the blood 
D)  Presence of CRAB features

Question 9

A patient whose malignant clone is positive for the CD markers CD15 and CD30 is most likely to have what clinical disease?

Accepted Answer

A)  Non-Hodgkin lymphoma 
B)  Hodgkin lymphoma 
C)  Acute lymphocytic leukemia 
D)  Hairy-cell leukemia 
A)  Non-Hodgkin lymphoma 
B)  Hodgkin lymphoma 
C)  Acute lymphocytic leukemia 
D)  Hairy-cell leukemia

Question 10

Which marker is highly specific for hairy-cell leukemia?

Accepted Answer

A)  CD19 
B)  CD20 
C)  CD25 
D)  CD103 
A)  CD19 
B)  CD20 
C)  CD25 
D)  CD103

Which type of gene is required for cell growth and division but can cause malignant transformation when altered?

What is the correct order of protein migration,starting at the cathode and moving to anode,following serum protein electrophoresis?

A patient's immunofixation electrophoresis shows excessive amounts of free monoclonal light chains.These light chains are referred to as:

Malignant plasma cells exhibiting CD38,CD56,and CD138 are found in:

Which cytogenetic abnormality is associated with an excellent prognosis in children with B-cell acute lymphoblastic leukemia (ALL)?

Which statement regarding myelogenous leukemias is true?

Which of the following is not a characteristic in the identification of lymphoma of B-cell origin?

Which of the following findings is a diagnostic criterion for monoclonal gammopathy of undetermined significance?

A patient whose malignant clone is positive for the CD markers CD15 and CD30 is most likely to have what clinical disease?

Which marker is highly specific for hairy-cell leukemia?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

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Exam 18: Immunoproliferative Diseases

Which type of gene is required for cell growth and division but can cause malignant transformation when altered?

What is the correct order of protein migration,starting at the cathode and moving to anode,following serum protein electrophoresis?

A patient's immunofixation electrophoresis shows excessive amounts of free monoclonal light chains.These light chains are referred to as:

Malignant plasma cells exhibiting CD38,CD56,and CD138 are found in:

Which cytogenetic abnormality is associated with an excellent prognosis in children with B-cell acute lymphoblastic leukemia (ALL)?

Which statement regarding myelogenous leukemias is true?

Which of the following is not a characteristic in the identification of lymphoma of B-cell origin?

Which of the following findings is a diagnostic criterion for monoclonal gammopathy of undetermined significance?

A patient whose malignant clone is positive for the CD markers CD15 and CD30 is most likely to have what clinical disease?

Which marker is highly specific for hairy-cell leukemia?

Introduction to Immunity and the Immune System

Nature of Antigens and the Major Histocompatibility Complex

Innate Immunity

Adaptive Immunity

Antibody Structure and Function

Cytokines

Complement System

Safety and Quality Management

Principles of Serological Testing

Precipitation and Agglutination Reactions

Labeled Immunoassays

Molecular Diagnostic Techniques

Flow Cytometry and Laboratory Automation

Hypersensitivity

Autoimmunity

Transplantation Immunology

Tumor Immunology

Immunodeficiency Diseases

Serological and Molecular Detection of Bacterial Infections

Spirochete Diseases

Serological and Molecular Diagnosis of Parasitic and Fungal Infections

Serology and Molecular Detection of Viral Infections

Laboratory Diagnosis of HIV Infection

Immunization and Vaccines

Filters