Deck 17: Defects of Plasma Clotting Factors

Question 1

All of the following may lead to deficiencies of clotting factors except:

A)Renal disease
B)Liver disease
C)Autoimmune disease
D)Cardiovascular disease

Answer 1

D

Question 2

Long-term antibiotic therapy is a cause of bleeding because it disrupts:

A)Vitamin K synthesis
B)Contact activation
C)Platelet aggregation
D)Fibrinolytic activity

Answer 2

A

Question 3

The treatment of choice for hemophilia A individuals is:

A)Cryoprecipitate
B)Recombinant factor VIII
C)Prothrombin complex
D)DDAVP

Answer 3

B

Question 4

Which of the following is not a vitamin K-dependent factor?

A)Factor VIII
B)Factor II
C)Factor VII
D)Factor IX

Question 5

Patients with hemophilia A or B have abnormal results in which coagulation assay?

A)APTT
B)PT
C)Fibrinogen assay
D)Platelet count

Question 6

Which of the following is the most prevalent inherited bleeding disorder?

A)Hemophilia A
B)Hemophilia B
C)Factor VII deficiency
D)von Willebrand Disease

Question 7

A patient with 8% factor VIII activity has which form of hemophilia?

A)Severe
B)Moderate
C)Mild
D)Asymptomatic

Question 8

Which of the following is the most useful in differentiating hemophilia A from hemophilia B?

A)A familial pattern of inheritance
B)Patient's history
C)Activated partial thromboplastin time
D)Factor assays

Question 9

Keloid scar formation is most commonly associated with:

A)Factor VIII deficiency
B)Factor IX deficiency
C)Factor XII deficiency
D)Factor XIII deficiency

Question 10

A man with hemophilia A and an unaffected female can produce a:

A)Female carrier
B)Male carrier
C)Male with hemophilia A
D)Normal female

Question 11

The only clotting factor not synthesized exclusively by the liver is factor:

A)V
B)VII
C)VIII
D)IX

Question 12

Christmas disease is another name for:

A)Hemophilia A
B)Hemophilia B
C)von Willebrand's disease
D)Factor VII deficiency

Question 13

Treatment of patients with factor II, VII, or X deficiency consists of:

A)Administration of prothrombin complex concentrate
B)Administration of cryoprecipitate
C)Administration of FFP
D)Administration of whole blood

Question 14

The following laboratory results have been obtained for a 40-year-old woman with infrequent bleeding: PT = 20 seconds (reference range is 11 to 15 seconds), APTT = 50 seconds (reference range is 22 to 40 seconds).What factor deficiency is most likely?

A)VII
B)VIII
C)X
D)XIII

Question 15

Factor assays measure the percentage of activity of a given factor by mixing the patient's plasma with:

A)Normal plasma
B)Adsorbed plasma
C)Factor-deficient plasma
D)Factor-specific plasma

Question 16

Factor VIII is also known as which?

A)X factor
B)Plasminogen
C)Christmas factor
D)Antihemophilic globulin

Question 17

Clotting factors must be present at a minimum of which percentage for hemostasis to be achieved?

A)20%
B)30%
C)50%
D)75%

Question 18

What is a new treatment alternative for hemophilia patients?

A)Recombinant factor VIII
B)Fresh frozen plasma
C)Gene therapy
D)Cryoprecipitate

Question 19

Which of the following assays will be abnormal with hemophilia A?

A)Platelet count
B)Bleeding time
C)PT
D)aPTT