Deck 15: Cancer Genetics

Question 1

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?
a.structural genes
b.metabolism genes
c.DNA-repair genes
d.nuclear-import genes

Answer 1

DNA - repair genes

Question 2

Which of the following is true of tumor-suppressor genes?
a.Their normal function is to promote cell proliferation.
b.Their mutant forms are typically dominant.
c.They were the first cancer-causing genes to be identified.
d.None of the above is true of tumor-suppressor genes.

Answer 2

None of the above is true of tumor-suppressor genes.

Question 3

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication.
a.stronger; unregulated
b.stronger; tightly regulated
c.weaker; unregulated
d.weaker; tightly regulated

Answer 3

weaker; unregulated

Question 4

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?
a.DNA-repair genes
b.retinoblastoma
c.palladin
d.telomerase
e.ras