Question 1

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

Accepted Answer

A) structural genes 
B) metabolism genes 
C) DNA-repair genes 
D) nuclear-import genes 
A) structural genes 
B) metabolism genes 
C) DNA-repair genes 
D) nuclear-import genes C

Question 2

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication.

Accepted Answer

A) stronger; unregulated 
B) stronger; tightly regulated 
C) weaker; unregulated 
D) weaker; tightly regulated 
A) stronger; unregulated 
B) stronger; tightly regulated 
C) weaker; unregulated 
D) weaker; tightly regulated C

Question 3

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Accepted Answer

A) DNA-repair genes 
B) retinoblastoma 
C) palladin 
D) telomerase 
E) ras 
A) DNA-repair genes 
B) retinoblastoma 
C) palladin 
D) telomerase 
E) ras D

Question 4

Which of the following is true of tumor-suppressor genes?

Accepted Answer

A) Their normal function is to promote cell proliferation. 
B) Their mutant forms are typically dominant. 
C) They were the first cancer-causing genes to be identified. 
D) None of the above is true of tumor-suppressor genes. 
A) Their normal function is to promote cell proliferation. 
B) Their mutant forms are typically dominant. 
C) They were the first cancer-causing genes to be identified. 
D) None of the above is true of tumor-suppressor genes.

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a association between RB and E2F,with _ transcription of genes necessary for DNA replication.

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Which of the following is true of tumor-suppressor genes?

Introduction to Genetics

Chromosomes and Cellular Reproduction

Basic Principles of Heredity

Extensions and Modifications of Basic Principles

Linkage, Recombination, and Eukaryotic Gene Mapping

Bacterial and Viral Genetic Systems

Chromosome Variation

DNA: The Chemical Nature of the Gene

DNA Replication

From DNA to Proteins: Transcription and Rna Processing

From DNA to Proteins: Translation

Control of Gene Expression

Gene Mutations, Transposable Elements, and Dna Repair

Molecular Genetic Analysis, Biotechnology, and Genomics

Quantitative Genetics

Population and Evolutionary Genetics

Filters

Exam 15: Cancer Genetics

Considering the clonal evolution of tumors,mutations in which kinds of genes would speed up the rate of mutations?

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a ______ association between RB and E2F,with _______ transcription of genes necessary for DNA replication.

In cancer cells you notice that the chromosomes are not shortening,even after many cell divisions.A mutation in the expression of which gene might lead to this observation?

Which of the following is true of tumor-suppressor genes?

Introduction to Genetics

Chromosomes and Cellular Reproduction

Basic Principles of Heredity

Extensions and Modifications of Basic Principles

Linkage, Recombination, and Eukaryotic Gene Mapping

Bacterial and Viral Genetic Systems

Chromosome Variation

DNA: The Chemical Nature of the Gene

DNA Replication

From DNA to Proteins: Transcription and Rna Processing

From DNA to Proteins: Translation

Control of Gene Expression

Gene Mutations, Transposable Elements, and Dna Repair

Molecular Genetic Analysis, Biotechnology, and Genomics

Quantitative Genetics

Population and Evolutionary Genetics

Filters

In an experiment you mutate the retinoblastoma gene RBsuch that its gene product behaves as if hyperphosphorylated.The result would be a association between RB and E2F,with _ transcription of genes necessary for DNA replication.