Deck 27: Tolerance, Autoimmunity, and Autoimmune Diseases

Question 1

Anticardiolipin antibody is associated with

A)rheumatoid arthritis (RA).
B)multiple sclerosis (MS).
C)pernicious anemia (PA).
D)systemic lupus erythematosus (SLE).

Answer 1

systemic lupus erythematosus (SLE).

Question 2

The basic immunologic mechanism responsible for autoimmune disorders is related to

A)activated T lymphocytes.
B)failure to activate B lymphocytes.
C)defective phagocytosis.
D)deposition of circulating immune complexes.

Answer 2

deposition of circulating immune complexes.

Question 3

Anti-DNA antibody is associated with

A)rheumatoid arthritis (RA).
B)multiple sclerosis (MS).
C)pernicious anemia (PA).
D)systemic lupus erythematosus (SLE).

Answer 3

systemic lupus erythematosus (SLE).

Question 4

Most immunologically mediated renal diseases fall into one of the following categories, except

A)association with circulating immune complexes.
B)association with circulating antigen.
C)association with anti-glomerular basement membrane antibody.
D)membranoproliferative glomerulonephritis.

Question 5

Self-recognition (tolerance) is induced by

A)elimination of the small clone of immunocompetent cells programmed to react with the antigen.
B)induction of unresponsiveness in immunocompetent cells.
C)induction of unresponsiveness through triggering of a suppressor mechanism.
D)All of the above.

Question 6

Match the statements with the correct type of disorder (a or b).
Lesions caused by deposition of antigen-antibody (immune) complexes.

A)Organ-specific
B)Organ-nonspecific

Question 7

An individual may develop an autoimmune response to

A)antigens that do not normally circulate in the blood.
B)altered antigens.
C)loss of immunoregulatory function by lymphocyte subsets.
D)All of the above.

Question 8

Match the statements with the correct type of disorder (a or b).
Antigens accessible at higher concentrations.

A)Organ-specific
B)Organ-nonspecific

Question 9

The cause of insulin-dependent diabetes mellitus is

A)immune destruction of beta cells in pancreatic islets.
B)immune destruction of delta cells in pancreatic islets.
C)anti-parietal cell antibody.
D)anti-islet cell antigen.

Question 10

Match the statements with the correct type of disorder (a or b).
Antigens only available to lymphoid system in low concentrations.

A)Organ-specific
B)Organ-nonspecific

Question 11

The immunologic manifestations of multiple sclerosis (MS) include all the following except:

A)antimyelin antibodies.
B)an oligoclonal increase in CSF immunoglobulin.
C)T cell-dependent inflammatory demyelination.
D)myelin antibodies are detectable in the CSF.

Question 12

The definition of autoimmunity is a(n)

A)increase in tolerance to self-antigens.
B)increase in immunosuppressive activities.
C)increased sensitivity to foreign antigens.
D)decreased tolerance to self-antigens.

Question 13

Antibodies demonstrated in pernicious anemia (PA) include

A)anti-intrinsic factor.
B)antiparietal.
C)antiinsulin.
D)Both A and B.

Question 14

Pernicious anemia (PA) is characterized by

A)deficiency of vitamin B12.
B)presence of antiparietal antibodies.
C)presence of intrinsic factor (IF)-blocking antibodies.
D)All of the above.

Question 15

An early marker of beta pancreatic cell destruction is _________________ antibody.

A)anti-DNA
B)anti-islet cell
C)antinuclear
D)anti-intrinsic factor

Question 16

Match the statements with the correct type of disorder (a or b).
Tendency to develop cancer in the organ.

A)Organ-specific
B)Organ-nonspecific

Question 17

Match the statements with the correct type of disorder (a or b).
Parenchymal destruction by questionable cell-mediated hypersensitivity or antibodies.

A)Organ-specific
B)Organ-nonspecific

Question 18

Which of the following disorders is considered to be organ-nonspecific?

A)Systemic lupus erythematosus
B)Insulin-dependent diabetes (type 1)
C)Hashimoto's thyroiditis
D)Carditis

Question 19

Match the statements with the correct type of disorder (a or b).
Familial tendency to develop connective tissue disease.

A)Organ-specific
B)Organ-nonspecific

Question 20

Antimyelin antibody is associated with

A)rheumatoid arthritis (RA).
B)multiple sclerosis (MS).
C)pernicious anemia (PA).
D)systemic lupus erythematosus (SLE).

Question 21

Match the statements with the correct type of disorder (a or b).
Tendency to develop lymphoreticular neoplasia.

A)Organ-specific
B)Organ-nonspecific

Question 22

Match the term with the appropriate definition.
Anti-parietal cell antibody

A)Measures antibody to nuclear antigens
B)Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes
C)An antibody to a basic nonhistone nuclear protein
D)Found in about 80% of patients with pernicious anemia

Question 23

Match the term with the appropriate definition.
Anti-Scl antibody

A)Measures antibody to nuclear antigens
B)Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes
C)An antibody to a basic nonhistone nuclear protein
D)Found in about 80% of patients with pernicious anemia

Question 24

Match the term with the appropriate definition.
Antineutrophil antibody

A)Measures antibody to nuclear antigens
B)Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes
C)An antibody to a basic nonhistone nuclear protein
D)Found in about 80% of patients with pernicious anemia

Question 25

Match the term with the appropriate definition.
ANA

A)Measures antibody to nuclear antigens
B)Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes
C)An antibody to a basic nonhistone nuclear protein
D)Found in about 80% of patients with pernicious anemia