Question 1

An early marker of beta pancreatic cell destruction is _________________ antibody.

Accepted Answer

A) anti-DNA 
B) anti-islet cell 
C) antinuclear 
D) anti-intrinsic factor 
A) anti-DNA 
B) anti-islet cell 
C) antinuclear 
D) anti-intrinsic factor B

Question 2

Anticardiolipin antibody is associated with

Accepted Answer

A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) . 
A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) . D

Question 3

Match the term with the appropriate definition.
-Antineutrophil antibody

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia B

Question 4

Self-recognition (tolerance) is induced by

Accepted Answer

A) elimination of the small clone of immunocompetent cells programmed to react with the antigen. 
B) induction of unresponsiveness in immunocompetent cells. 
C) induction of unresponsiveness through triggering of a suppressor mechanism. 
D) All of the above. 
A) elimination of the small clone of immunocompetent cells programmed to react with the antigen. 
B) induction of unresponsiveness in immunocompetent cells. 
C) induction of unresponsiveness through triggering of a suppressor mechanism. 
D) All of the above.

Question 5

Match the statements with the correct type of disorder (a or b).
-Antigens only available to lymphoid system in low concentrations.

Accepted Answer

A) Organ-specific 
B) Organ-nonspecific 
A) Organ-specific 
B) Organ-nonspecific

Question 6

The definition of autoimmunity is a(n)

Accepted Answer

A) increase in tolerance to self-antigens. 
B) increase in immunosuppressive activities. 
C) increased sensitivity to foreign antigens. 
D) decreased tolerance to self-antigens. 
A) increase in tolerance to self-antigens. 
B) increase in immunosuppressive activities. 
C) increased sensitivity to foreign antigens. 
D) decreased tolerance to self-antigens.

Question 7

Antimyelin antibody is associated with

Accepted Answer

A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) . 
A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) .

Question 8

Match the term with the appropriate definition.
-ANA

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia

Question 9

Antibodies demonstrated in pernicious anemia (PA) include

Accepted Answer

A) anti-intrinsic factor. 
B) antiparietal. 
C) antiinsulin. 
D) Both A and B. 
A) anti-intrinsic factor. 
B) antiparietal. 
C) antiinsulin. 
D) Both A and B.

Question 10

Pernicious anemia (PA) is characterized by

Accepted Answer

A) deficiency of vitamin B12. 
B) presence of antiparietal antibodies. 
C) presence of intrinsic factor (IF)-blocking antibodies. 
D) All of the above. 
A) deficiency of vitamin B12. 
B) presence of antiparietal antibodies. 
C) presence of intrinsic factor (IF)-blocking antibodies. 
D) All of the above.

Question 11

The basic immunologic mechanism responsible for autoimmune disorders is related to

Accepted Answer

A) activated T lymphocytes. 
B) failure to activate B lymphocytes. 
C) defective phagocytosis. 
D) deposition of circulating immune complexes. 
A) activated T lymphocytes. 
B) failure to activate B lymphocytes. 
C) defective phagocytosis. 
D) deposition of circulating immune complexes.

Question 12

Match the statements with the correct type of disorder (a or b).
-Tendency to develop lymphoreticular neoplasia.

Accepted Answer

A) Organ-specific 
B) Organ-nonspecific 
A) Organ-specific 
B) Organ-nonspecific

Question 13

-An individual may develop an autoimmune response to

Accepted Answer

A) antigens that do not normally circulate in the blood. 
B) altered antigens. 
C) loss of immunoregulatory function by lymphocyte subsets. 
D) All of the above. 
A) antigens that do not normally circulate in the blood. 
B) altered antigens. 
C) loss of immunoregulatory function by lymphocyte subsets. 
D) All of the above.

Question 14

Anti-DNA antibody is associated with

Accepted Answer

A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) . 
A) rheumatoid arthritis (R
A) . 
B) multiple sclerosis (MS). 
C) pernicious anemia (P
A) . 
D) systemic lupus erythematosus (SL
E) .

Question 15

The immunologic manifestations of multiple sclerosis (MS) include all the following except:

Accepted Answer

A) antimyelin antibodies. 
B) an oligoclonal increase in CSF immunoglobulin. 
C) T cell-dependent inflammatory demyelination. 
D) myelin antibodies are detectable in the CSF. 
A) antimyelin antibodies. 
B) an oligoclonal increase in CSF immunoglobulin. 
C) T cell-dependent inflammatory demyelination. 
D) myelin antibodies are detectable in the CSF.

Question 16

Which of the following disorders is considered to be organ-nonspecific?

Accepted Answer

A) Systemic lupus erythematosus 
B) Insulin-dependent diabetes (type 1) 
C) Hashimoto's thyroiditis 
D) Carditis 
A) Systemic lupus erythematosus 
B) Insulin-dependent diabetes (type 1) 
C) Hashimoto's thyroiditis 
D) Carditis

Question 17

Match the statements with the correct type of disorder (a or b).
-Familial tendency to develop connective tissue disease.

Accepted Answer

A) Organ-specific 
B) Organ-nonspecific 
A) Organ-specific 
B) Organ-nonspecific

Question 18

The cause of insulin-dependent diabetes mellitus is

Accepted Answer

A) immune destruction of beta cells in pancreatic islets. 
B) immune destruction of delta cells in pancreatic islets. 
C) anti-parietal cell antibody. 
D) anti-islet cell antigen. 
A) immune destruction of beta cells in pancreatic islets. 
B) immune destruction of delta cells in pancreatic islets. 
C) anti-parietal cell antibody. 
D) anti-islet cell antigen.

Question 19

Match the term with the appropriate definition.
-Anti-Scl antibody

Accepted Answer

A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia 
A) Measures antibody to nuclear antigens 
B) Produces a characteristic granular cytoplasmic staining pattern to cytoplasmic constituents of granulocytes 
C) An antibody to a basic nonhistone nuclear protein 
D) Found in about 80% of patients with pernicious anemia

Question 20

Match the statements with the correct type of disorder (a or b).
-Parenchymal destruction by questionable cell-mediated hypersensitivity or antibodies.

Accepted Answer

A) Organ-specific 
B) Organ-nonspecific 
A) Organ-specific 
B) Organ-nonspecific

Exam 27: Tolerance, Autoimmunity, and Autoimmune Diseases

An early marker of beta pancreatic cell destruction is _________________ antibody.

Anticardiolipin antibody is associated with

Match the term with the appropriate definition. -Antineutrophil antibody

Self-recognition (tolerance) is induced by

Match the statements with the correct type of disorder (a or b). -Antigens only available to lymphoid system in low concentrations.

The definition of autoimmunity is a(n)

Antimyelin antibody is associated with

Match the term with the appropriate definition. -ANA

Antibodies demonstrated in pernicious anemia (PA) include

Pernicious anemia (PA) is characterized by

The basic immunologic mechanism responsible for autoimmune disorders is related to

Match the statements with the correct type of disorder (a or b). -Tendency to develop lymphoreticular neoplasia.

-An individual may develop an autoimmune response to

Anti-DNA antibody is associated with

The immunologic manifestations of multiple sclerosis (MS) include all the following except:

Which of the following disorders is considered to be organ-nonspecific?

Match the statements with the correct type of disorder (a or b). -Familial tendency to develop connective tissue disease.

The cause of insulin-dependent diabetes mellitus is

Match the term with the appropriate definition. -Anti-Scl antibody

Match the statements with the correct type of disorder (a or b). -Parenchymal destruction by questionable cell-mediated hypersensitivity or antibodies.

An Overview of Immunology

Antigens and Antibodies

Cells and Cellular Activities of the Immune System: Granulocytes and Mononuclear Cells

Cells and Cellular Activities of the Immune System: Lymphocytes and Plasma Cells

Soluble Mediators of the Immune System

Safety in the Immunology-Serology Laboratory

Quality Assurance and Quality Control

Basic Serologic Laboratory Techniques

Rapid Testing

Precipitation and Particle Agglutination Methods

Electrophoresis Techniques

Labeling Techniques in Immunoassay

Flow Cytometry

Molecular Laboratory Techniques

Infectious Diseases: Traditional and Alternate Diagnostic Techniques

Streptococcal Infections

Syphilis

Vector-Borne Diseases

Toxoplasmosis

Cytomegalovirus

Infectious Mononucleosis

Viral Hepatitis

Rubella and Rubeola Infections

Primary and Acquired Immune Deficiency Syndromes

Hypersensitivity Reactions

Immunoproliferative Disorders

Systemic Lupus Erythematosus

Rheumatoid Arthritis

Transplantation: Hla, Solid Organ, and Hematopoietic Stem Cells

Tumor Immunology and Up-To-Date Applications of Next-Generation Sequencing

Primer on Vaccines

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