Deck 20: Immunity to Tumors

Question 1

Matching
For each particular tumor antigen listed in questions 1-5, choose the class of tumor antigen (A-G) to which it belongs.
Prostate-specific antigen

A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus

Answer 1

Tissue differentiation antigen

Question 2

For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
Differentiation antigen for B cells

A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Answer 2

CD20

Question 3

For each of the descriptions in questions , select the tumor immunotherapy strategy (A-J) that is best match.
Component of adoptive cellular immunotherapy used with IL-2 and/or chemotherapeutic drugs

A)Killed tumor vaccine
B)DNA vaccines
C)Interleukin (IL)-2
D)IL-4
E)GM-CSF (granulocyte-macrophage colony-stimulating factor)
F)Anti-CD3 antibodies
G)Lymphokine-activated killer cells
H)Anti-Her2/neu antibodies
I)Anti-idiotypic antibodies
J)Dendritic cell vaccine

Answer 3

Lymphokine-activated killer cells

Question 4

Matching
For each particular tumor antigen listed in questions 1-5, choose the class of tumor antigen (A-G) to which it belongs.
Carcinoembryonic antigen (CEA)

A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus

Question 5

For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
Mutations in both allelic copies of this gene are required for malignant transformation

A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Question 6

For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
A protein that is expressed only in immunologically privileged tissue

A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Question 7

For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
A patient presenting with jaundice and a recent 11-kg (20 lb) weight loss who has a history of hepatitis B infection will most likely have elevated levels of this glycoprotein

A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Question 8

A 17-year-old girl from southern China has had a sore throat and fever for 1 week. On physical examination, generalized lymphadenopathy is noted. A rapid strep test for streptococcal infection is negative and a CBC shows 20% atypical lymphocytes. A Monospot test for the presence of heterophile antibodies is positive. This illness is associated with eventual development of which of the following malignancies?

A) Kaposi's sarcoma
B) Cervical carcinoma
C) Follicular lymphoma
D) Human T cell lymphoma
E) Nasopharyngeal carcinoma

Question 9

For each of the descriptions in questions , select the tumor immunotherapy strategy (A-J) that is best match.
Therapy that targets an antigen that is not essential to the malignant phenotype of the tumor; antigen-loss variants can emerge during therapy

A)Killed tumor vaccine
B)DNA vaccines
C)Interleukin (IL)-2
D)IL-4
E)GM-CSF (granulocyte-macrophage colony-stimulating factor)
F)Anti-CD3 antibodies
G)Lymphokine-activated killer cells
H)Anti-Her2/neu antibodies
I)Anti-idiotypic antibodies
J)Dendritic cell vaccine

Question 10

Matching
For each particular tumor antigen listed in questions 1-5, choose the class of tumor antigen (A-G) to which it belongs.
E6 antigen

A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus

Question 11

For each of the descriptions in questions , select the tumor immunotherapy strategy (A-J) that is best match.
Tumor cells transfected with the gene encoding this protein have been used as a vaccine that promotes dendritic cell presentation of tumor antigens

A)Killed tumor vaccine
B)DNA vaccines
C)Interleukin (IL)-2
D)IL-4
E)GM-CSF (granulocyte-macrophage colony-stimulating factor)
F)Anti-CD3 antibodies
G)Lymphokine-activated killer cells
H)Anti-Her2/neu antibodies
I)Anti-idiotypic antibodies
J)Dendritic cell vaccine

Question 12

For each description in questions , choose the tumor antigen or gene (A-J) that is the best match.
A mucin that is often elevated in ovarian carcinoma

A)AFP
B)Bcr/Abl
C)CA-125
D)CD20
E)CEA
F)EBNA
G)MAGE
H)p53
I)PSA
J)Ras

Question 13

Matching
For each particular tumor antigen listed in questions 1-5, choose the class of tumor antigen (A-G) to which it belongs.
Ras

A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus

Question 14

Matching
For each particular tumor antigen listed in questions 1-5, choose the class of tumor antigen (A-G) to which it belongs.
Cancer testis antigens

A)Product of a cellular oncogene
B)Overexpressed unmutated cellular proteins
C)Product of unmutated genes normally silent in most tissues
D)Overexpressed surface glycolipid
E)Oncofetal antigen
F)Tissue differentiation antigen
G)Product of an oncogenic virus