Deck 4: Antigen Presenting Molecules

Question 1

Why are HLA heterozygotes more resistant to disease than homozygotes?

A) They have more single nucleotide polymorphisms.
B) They have a more diverse range of minor HLA loci.
C) They have more diversity in the antibodies they produce.
D) They have a more varied repertoire of antigen-presenting HLA molecules.

Answer 1

They have a more varied repertoire of antigen-presenting HLA molecules.

Question 2

HLA class III genes produce:

A) Stress molecules
B) Complement components
C) Antigen presenting molecules
D) Receptors that activate natural killer (NK) cells

Answer 2

Complement components

Question 3

CD1 molecules are similar in structure to:
I- HLA class I molecules
III- HLA class II molecules
III- HLA class III molecules

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 3

I only

Question 4

HLA class II molecule consists of:

A) Three glycosylated a-chains
B) Heavily glycosylated a- and b-chain
C) Two glycosylated a-chains and three b-chains
D) A single glycosylated a-chain bound to b2-microglobulin

Question 5

Human leukocyte antigen (HLA) class I molecules bind antigens:

A) At the ends and the antigens are larger than HLA class II antigens
B) At the ends and the antigens are smaller than HLA class II antigens
C) In the middle and the antigens are larger than HLA class II antigens
D) In the middle and the antigens are smaller than HLA class II antigens

Question 6

In bare lymphocyte syndrome, individuals lack which surface molecules on their lymphocytes?

A) CD4
B) CD8
C) HLA class I molecules
D) HLA class II molecules

Question 7

Allelic polymorphism assures that some members of a species will survive a microbial infection because the different alleles:

A) Better distinguish between foreign and self
B) Provide receptors with greater affinity for antigen
C) Allow the immune system to respond to a wide range of antigens
D) Produce a greater variety of cytokines to assist in the immune response

Question 8

A set of HLA antigens on the same chromosome is called a:

A) Gene
B) Hapten
C) Haplotype
D) Single nucleotide polymorphism (SNP)

Question 9

Which of the following molecules are capable of presenting antigen?
I. CD1 molecules
II. HLA class I molecules
III. HLA class II molecules

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question 10

Individuals who express HLA-DR13:

A) Can more easily clear hepatitis B virus
B) Are more susceptible to tuberculosis infection
C) Are more susceptible to Candida albicans infections
D) Can more easily eliminate respiratory syncytial virus (RSV)