Question 1

Why are HLA heterozygotes more resistant to disease than homozygotes?

Accepted Answer

A)  They have more single nucleotide polymorphisms. 
B)  They have a more diverse range of minor HLA loci. 
C)  They have more diversity in the antibodies they produce. 
D)  They have a more varied repertoire of antigen-presenting HLA molecules. 
A)  They have more single nucleotide polymorphisms. 
B)  They have a more diverse range of minor HLA loci. 
C)  They have more diversity in the antibodies they produce. 
D)  They have a more varied repertoire of antigen-presenting HLA molecules. D

Question 2

Which of the following molecules are capable of presenting antigen? 
I. CD1 molecules
II. HLA class I molecules
III. HLA class II molecules

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III E

Question 3

Allelic polymorphism assures that some members of a species will survive a microbial infection because the different alleles:

Accepted Answer

A)  Better distinguish between foreign and self 
B)  Provide receptors with greater affinity for antigen 
C)  Allow the immune system to respond to a wide range of antigens 
D)  Produce a greater variety of cytokines to assist in the immune response 
A)  Better distinguish between foreign and self 
B)  Provide receptors with greater affinity for antigen 
C)  Allow the immune system to respond to a wide range of antigens 
D)  Produce a greater variety of cytokines to assist in the immune response C

Question 4

Human leukocyte antigen (HLA) class I molecules bind antigens:

Accepted Answer

A)  At the ends and the antigens are larger than HLA class II antigens 
B)  At the ends and the antigens are smaller than HLA class II antigens 
C)  In the middle and the antigens are larger than HLA class II antigens 
D)  In the middle and the antigens are smaller than HLA class II antigens 
A)  At the ends and the antigens are larger than HLA class II antigens 
B)  At the ends and the antigens are smaller than HLA class II antigens 
C)  In the middle and the antigens are larger than HLA class II antigens 
D)  In the middle and the antigens are smaller than HLA class II antigens

Question 5

CD1 molecules are similar in structure to:
I- HLA class I molecules
III- HLA class II molecules
III- HLA class III molecules

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Question 6

A set of HLA antigens on the same chromosome is called a:

Accepted Answer

A)  Gene 
B)  Hapten 
C)  Haplotype 
D)  Single nucleotide polymorphism (SNP) 
A)  Gene 
B)  Hapten 
C)  Haplotype 
D)  Single nucleotide polymorphism (SNP)

Question 7

HLA class III genes produce:

Accepted Answer

A)  Stress molecules 
B)  Complement components 
C)  Antigen presenting molecules 
D)  Receptors that activate natural killer (NK) cells 
A)  Stress molecules 
B)  Complement components 
C)  Antigen presenting molecules 
D)  Receptors that activate natural killer (NK) cells

Question 8

Individuals who express HLA-DR13:

Accepted Answer

A)  Can more easily clear hepatitis B virus 
B)  Are more susceptible to tuberculosis infection 
C)  Are more susceptible to Candida albicans infections 
D)  Can more easily eliminate respiratory syncytial virus (RSV) 
A)  Can more easily clear hepatitis B virus 
B)  Are more susceptible to tuberculosis infection 
C)  Are more susceptible to Candida albicans infections 
D)  Can more easily eliminate respiratory syncytial virus (RSV)

Question 9

In bare lymphocyte syndrome, individuals lack which surface molecules on their lymphocytes?

Accepted Answer

A)  CD4 
B)  CD8 
C)  HLA class I molecules 
D)  HLA class II molecules 
A)  CD4 
B)  CD8 
C)  HLA class I molecules 
D)  HLA class II molecules

Question 10

HLA class II molecule consists of:

Accepted Answer

A)  Three glycosylated a-chains 
B)  Heavily glycosylated a- and b-chain 
C)  Two glycosylated a-chains and three b-chains 
D)  A single glycosylated a-chain bound to b2-microglobulin 
A)  Three glycosylated a-chains 
B)  Heavily glycosylated a- and b-chain 
C)  Two glycosylated a-chains and three b-chains 
D)  A single glycosylated a-chain bound to b2-microglobulin

Why are HLA heterozygotes more resistant to disease than homozygotes?

Which of the following molecules are capable of presenting antigen? I. CD1 molecules II. HLA class I molecules III. HLA class II molecules

Allelic polymorphism assures that some members of a species will survive a microbial infection because the different alleles:

Human leukocyte antigen (HLA) class I molecules bind antigens:

CD1 molecules are similar in structure to: I- HLA class I molecules III- HLA class II molecules III- HLA class III molecules

A set of HLA antigens on the same chromosome is called a:

HLA class III genes produce:

Individuals who express HLA-DR13:

In bare lymphocyte syndrome, individuals lack which surface molecules on their lymphocytes?

HLA class II molecule consists of:

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 4: Antigen Presenting Molecules

Why are HLA heterozygotes more resistant to disease than homozygotes?

Which of the following molecules are capable of presenting antigen? I. CD1 molecules II. HLA class I molecules III. HLA class II molecules

Allelic polymorphism assures that some members of a species will survive a microbial infection because the different alleles:

Human leukocyte antigen (HLA) class I molecules bind antigens:

CD1 molecules are similar in structure to: I- HLA class I molecules III- HLA class II molecules III- HLA class III molecules

A set of HLA antigens on the same chromosome is called a:

HLA class III genes produce:

Individuals who express HLA-DR13:

In bare lymphocyte syndrome, individuals lack which surface molecules on their lymphocytes?

HLA class II molecule consists of:

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters