Deck 6: Surface Interactions Between T Cells and Antigen-Presenting Cells

Question 1

T cells with the g/d TCR are primarily located in the:

A) Bone marrow
B) Lymph nodes
C) Mucosal tissue
D) Peripheral blood

Answer 1

Mucosal tissue

Question 2

When individuals have a congenital defect in which they lack the CD40 ligand (CD40L) on activated T cells, the outcome of that defect is:

A) They are not able to make mature T or B cells
B) They are only able to make CD8 cells and no other types of T cells
C) They are only able to make IgM antibody and no other type of antibody
D) They are not able to any antibodies at all even though B and T cells are present

Answer 2

They are only able to make IgM antibody and no other type of antibody

Question 3

According to the clonal selection theory, the activated T cell clone produces:

A) Only memory cells
B) Daughter cells that all have the same TCR
C) Daughter cells with different TCRs on the same cell
D) Multiple types of clones that each have different TCRs

Answer 3

Daughter cells that all have the same TCR

Question 4

Why are the g/d T cells more similar to the innate immune response than the adaptive immune response?

A) They can present antigen to other T cells.
B) They are able to phagocytose pathogens.
C) They do not require activation to eliminate pathogens.
D) They recognize general features of pathogens rather than a specific epitope.

Question 5

How are superantigens able to uniquely activate large amounts of T cells?

A) Superantigens secrete many toxins that are able to activate many different T cells.
B) Superantigens are able to travel to the lymph node to interact directly with more T cells.
C) Superantigens bind to the TCR and MHC class II molecule outside the binding groove.
D) Superantigens bind to the TCR in the binding groove like other antigens but they have more epitopes than other antigens.

Question 6

CD4 molecules on T cells bind to:

A) CD40
B) B7 molecules
C) MHC class I molecules
D) MHC class II molecules

Question 7

How does alefacept function to reduce lesions in plaque psoriasis?

A) By blocking CD28/B7 interactions and causing T cell apoptosis
B) By blocking CTLA-4/B7 interactions and causing T cell apoptosis
C) By blocking CD2/CD58 interactions and preventing T cell activation
D) By binding to CD3 on activated T cells and preventing T cell activation

Question 8

Which of the complementarity-determining regions (CDRs) on the a/b TCR only have contact with the MHC class II molecule and do not have contact with the antigen?

A) CDR1s
B) CDR2s
C) CDR3s
D) CDR4s

Question 9

In the function of the TCR, the purpose of the CD3 complex is to:

A) Bind antigen
B) Transduce signals
C) Anchor the TCR in the membrane
D) Stabilize the interaction between the TCR and the APC

Question 10

The interaction between CTLA-4 and B7 leads to:

A) Downregulation of T cell signaling
B) Stabilization of the TCR/APC interaction
C) B cell activation and generation of memory cells
D) Production of proteins that regulate the cellular response to interleukin-2 (IL-2)