Question 1

T cells with the g/d TCR are primarily located in the:

Accepted Answer

A)  Bone marrow 
B)  Lymph nodes 
C)  Mucosal tissue 
D)  Peripheral blood 
A)  Bone marrow 
B)  Lymph nodes 
C)  Mucosal tissue 
D)  Peripheral blood C

Question 2

How are superantigens able to uniquely activate large amounts of T cells?

Accepted Answer

A)  Superantigens secrete many toxins that are able to activate many different T cells. 
B)  Superantigens are able to travel to the lymph node to interact directly with more T cells. 
C)  Superantigens bind to the TCR and MHC class II molecule outside the binding groove. 
D)  Superantigens bind to the TCR in the binding groove like other antigens but they have more epitopes than other antigens. 
A)  Superantigens secrete many toxins that are able to activate many different T cells. 
B)  Superantigens are able to travel to the lymph node to interact directly with more T cells. 
C)  Superantigens bind to the TCR and MHC class II molecule outside the binding groove. 
D)  Superantigens bind to the TCR in the binding groove like other antigens but they have more epitopes than other antigens. C

Question 3

The interaction between CTLA-4 and B7 leads to:

Accepted Answer

A)  Downregulation of T cell signaling 
B)  Stabilization of the TCR/APC interaction 
C)  B cell activation and generation of memory cells 
D)  Production of proteins that regulate the cellular response to interleukin-2 (IL-2) 
A)  Downregulation of T cell signaling 
B)  Stabilization of the TCR/APC interaction 
C)  B cell activation and generation of memory cells 
D)  Production of proteins that regulate the cellular response to interleukin-2 (IL-2) A

Question 4

In the function of the TCR, the purpose of the CD3 complex is to:

Accepted Answer

A)  Bind antigen 
B)  Transduce signals 
C)  Anchor the TCR in the membrane 
D)  Stabilize the interaction between the TCR and the APC 
A)  Bind antigen 
B)  Transduce signals 
C)  Anchor the TCR in the membrane 
D)  Stabilize the interaction between the TCR and the APC

Question 5

How does alefacept function to reduce lesions in plaque psoriasis?

Accepted Answer

A)  By blocking CD28/B7 interactions and causing T cell apoptosis 
B)  By blocking CTLA-4/B7 interactions and causing T cell apoptosis 
C)  By blocking CD2/CD58 interactions and preventing T cell activation 
D)  By binding to CD3 on activated T cells and preventing T cell activation 
A)  By blocking CD28/B7 interactions and causing T cell apoptosis 
B)  By blocking CTLA-4/B7 interactions and causing T cell apoptosis 
C)  By blocking CD2/CD58 interactions and preventing T cell activation 
D)  By binding to CD3 on activated T cells and preventing T cell activation

Question 6

Which of the complementarity-determining regions (CDRs) on the a/b TCR only have contact with the MHC class II molecule and do not have contact with the antigen?

Accepted Answer

A)  CDR1s 
B)  CDR2s 
C)  CDR3s 
D)  CDR4s 
A)  CDR1s 
B)  CDR2s 
C)  CDR3s 
D)  CDR4s

Question 7

Why are the g/d T cells more similar to the innate immune response than the adaptive immune response?

Accepted Answer

A)  They can present antigen to other T cells. 
B)  They are able to phagocytose pathogens. 
C)  They do not require activation to eliminate pathogens. 
D)  They recognize general features of pathogens rather than a specific epitope. 
A)  They can present antigen to other T cells. 
B)  They are able to phagocytose pathogens. 
C)  They do not require activation to eliminate pathogens. 
D)  They recognize general features of pathogens rather than a specific epitope.

Question 8

When individuals have a congenital defect in which they lack the CD40 ligand (CD40L) on activated T cells, the outcome of that defect is:

Accepted Answer

A)  They are not able to make mature T or B cells 
B)  They are only able to make CD8 cells and no other types of T cells 
C)  They are only able to make IgM antibody and no other type of antibody 
D)  They are not able to any antibodies at all even though B and T cells are present 
A)  They are not able to make mature T or B cells 
B)  They are only able to make CD8 cells and no other types of T cells 
C)  They are only able to make IgM antibody and no other type of antibody 
D)  They are not able to any antibodies at all even though B and T cells are present

Question 9

According to the clonal selection theory, the activated T cell clone produces:

Accepted Answer

A)  Only memory cells 
B)  Daughter cells that all have the same TCR 
C)  Daughter cells with different TCRs on the same cell 
D)  Multiple types of clones that each have different TCRs 
A)  Only memory cells 
B)  Daughter cells that all have the same TCR 
C)  Daughter cells with different TCRs on the same cell 
D)  Multiple types of clones that each have different TCRs

Question 10

CD4 molecules on T cells bind to:

Accepted Answer

A)  CD40 
B)  B7 molecules 
C)  MHC class I molecules 
D)  MHC class II molecules 
A)  CD40 
B)  B7 molecules 
C)  MHC class I molecules 
D)  MHC class II molecules

T cells with the g/d TCR are primarily located in the:

How are superantigens able to uniquely activate large amounts of T cells?

The interaction between CTLA-4 and B7 leads to:

In the function of the TCR, the purpose of the CD3 complex is to:

How does alefacept function to reduce lesions in plaque psoriasis?

Which of the complementarity-determining regions (CDRs) on the a/b TCR only have contact with the MHC class II molecule and do not have contact with the antigen?

Why are the g/d T cells more similar to the innate immune response than the adaptive immune response?

When individuals have a congenital defect in which they lack the CD40 ligand (CD40L) on activated T cells, the outcome of that defect is:

According to the clonal selection theory, the activated T cell clone produces:

CD4 molecules on T cells bind to:

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 6: Surface Interactions Between T Cells and Antigen-Presenting Cells

T cells with the g/d TCR are primarily located in the:

How are superantigens able to uniquely activate large amounts of T cells?

The interaction between CTLA-4 and B7 leads to:

In the function of the TCR, the purpose of the CD3 complex is to:

How does alefacept function to reduce lesions in plaque psoriasis?

Which of the complementarity-determining regions (CDRs) on the a/b TCR only have contact with the MHC class II molecule and do not have contact with the antigen?

Why are the g/d T cells more similar to the innate immune response than the adaptive immune response?

When individuals have a congenital defect in which they lack the CD40 ligand (CD40L) on activated T cells, the outcome of that defect is:

According to the clonal selection theory, the activated T cell clone produces:

CD4 molecules on T cells bind to:

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters