Deck 9: Antibodies

Question 1

During the anamnestic response, IgM-producing plasma cells switch to producing which type of antibody?

A) IgA
B) IgD
C) IgE
D) IgG

Answer 1

IgG

Question 2

The monomeric form of this antibody inserted into the B cell membrane serves as the B cell receptor (BCR):

A) IgA
B) IgE
C) IgG
D) IgM

Answer 2

IgM

Question 3

A patient has numerous skin lesions, including boils and abscesses, and has Staphylococcus aureus-induced lung disease. The patient also has coarse facial features and skeletal abnormalities. The patient exhibits high levels of IgE in the serum. The patient is most likely suffering from:

A) Job syndrome
B) Multiple myeloma
C) Waldenstrom's macroglobulinemia
D) Common variable immunodeficiency (CVID)

Answer 3

Job syndrome

Question 4

Antibodies with high affinity will be able to:

A) Tightly bind lower concentrations of antigen and quickly eliminate infection
B) Tightly bind higher concentrations of antigen and quickly eliminate infection
C) Loosely bind to lower concentrations of antigen and slowly eliminate infection
D) Loosely bind to higher concentrations of antigen and slowly eliminate infection

Question 5

A patient has bone pain, high calcium levels, high immunoglobulin levels, and Bence Jones proteins in their urine. The most likely diagnosis for this patient is:

A) Job syndrome
B) Multiple myeloma
C) Waldenstrom's macroglobulinemia
D) Common variable immunodeficiency (CVID)

Question 6

Which region of the antibody is important for physical flexibility of the antigen binding region?

A) J chain
B) Hinge region
C) Secretory piece
D) Variable regions

Question 7

Which of the following antibody regions is involved in antigen binding?
I. Light chain variable region
II. Heavy chain variable region
III. Heavy chain constant region

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question 8

Which class of antibody causes the release of histamine-containing granules of basophils and mast cells?

A) IgA
B) IgE
C) IgG
D) IgM

Question 9

Fab fragments can be used clinically to treat:

A) Job syndrome
B) Digoxin overdose
C) Multiple myeloma
D) Common variable immunodeficiency (CVID)

Question 10

An IgG2 subclass response is important for proper immunization with the meningococcal vaccine because:

A) IgG2 responds better to protein antigens
B) IgG2 responds better to carbohydrate antigens
C) Other IgG subclasses do not activate complement as efficiently
D) Other IgG subclasses are not always induced following vaccination