Deck 11: Complement

Question 1

In the alternative pathway, C3b can bind to which of the following?
I. To C3bBb
II. To factor B
III. The microbe cell surface

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 1

I, II, and III

Question 2

The role that C3d plays in the immune response to pathogens is:

A) Activation of B cells
B) Activation of CD4 and CD8 T cells
C) Activation of the alternative pathway
D) Activation of inhibitory factors of the complement pathways

Answer 2

Activation of B cells

Question 3

Which of the following are methods by which the C3 complement component can be cleaved?
I. Factor D
II. C3 convertase
III. Spontaneous cleavage

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 3

II and III

Question 4

The role that C3bBb3b plays in the complement pathway is to:

A) Cleave C2 to C2a and C2b
B) Cleave C3 to C3a and C3b
C) Cleave C4 to C4a and C4b
D) Cleave C5 to C5a and C5b

Question 5

What is the role of C9 in the complement pathways?

A) Creates pore
B) C3 convertase
C) C5 convertase
D) Binds to antibodies on microbe surface

Question 6

Which component is common to all three complement pathways?

A) C1
B) C2
C) C3
D) C4

Question 7

Patients with paroxysmal nocturnal hemoglobinuria lack which complement regulatory components on the host cell surfaces?

A) Factor H and Factor I
B) Decay accelerating factor (DAF) and CD59
C) Membrane cofactor protein (MCP) and C1INH
D) Homologous restriction factor (HRF) and properdin

Question 8

Which of the following components can act as an opsonin?

A) C1q
B) C3b
C) C4a
D) C5b

Question 9

Which of the following complement components acts as a chemoattractant?

A) C2a
B) C3a
C) C4b
D) C5b

Question 10

Which of the complement pathways requires antibodies for activation?
I. Lectin pathway
II. Alternative pathway
III. Classical pathway

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III