Deck 13: Antibodies and in Vivo Therapy

Question 1

Anti-Rh antibodies are used to treat:

A) Serum sickness
B) Kawasaki disease
C) Erythroblastosis fetalis
D) Idiopathic thrombocytopenic purpura (ITP)

Answer 1

Erythroblastosis fetalis

Question 2

Low platelet count and antibodies to platelets are signs of:

A) Serum sickness
B) Kawasaki disease
C) Erythroblastosis fetalis
D) Idiopathic thrombocytopenic purpura (ITP)

Answer 2

Idiopathic thrombocytopenic purpura (ITP)

Question 3

A monoclonal antibody used as a drug has a name that ends in what suffix?

A) U
B) Ab
C) Mab
D) Imm

Answer 3

Mab

Question 4

The main pathological target for autoantibodies found in patients with Kawasaki disease is:

A) Skin
B) Kidneys
C) Platelets
D) Vascular endothelial cells

Question 5

Radiolabeled antibodies to CD20, including tositumomab labeled with iodine-131, are frequently used to treat which disorder?

A) Multiple myeloma
B) Rheumatoid arthritis
C) Non-Hodgkin's lymphoma
D) Human immunodeficiency virus (HIV)

Question 6

Bispecific antibodies can react with:

A) Two different antigens
B) Two of the same antigen
C) Antigen and T cell or NK cell
D) Four different antigens on the same cell

Question 7

Hybridomas are fusion cells composed of:

A) B cells and T cells
B) Two different myeloma cells
C) Splenic B cells and myeloma cells
D) Lymph node B cells and splenic B cells

Question 8

Which of the following is an example of active immunity?

A) Antibody used therapeutically to treat lymphoma
B) Immunity to pneumococcal infection after exposure to the organism
C) Immunity acquired in a child by passage of antibodies from the mother's milk
D) Administration of pooled immunoglobulins from patients that had recovered from cytomegalovirus (CMV) to patients that currently have the disease

Question 9

A serious potential side effect of using antiserum therapy is the development of immune complexes that can lead to serious damage in the:

A) Brain
B) Lungs
C) Muscles
D) Kidneys

Question 10

Chimeric antibodies are a combination of:

A) Murine and yeast genes
B) Human and yeast genes
C) Human and murine genes
D) Murine genes from two different sources