Deck 17: Transplantation

Question 1

The main immune response in a case of chronic rejection of a transplanted organ is:

A) B cell activation
B) Both B and T cell activation
C) Allospecific T cell activation
D) Attack of organ by pre-existing antibodies

Answer 1

Both B and T cell activation

Question 2

Direct antigen presentation occurring during allogeneic graft rejection occurs when:

A) Donor APCs present antigen to the donor T cells
B) A recipient's T cells recognize donor cells as foreign
C) Donor antibodies bind to recipient cell surface molecules
D) A recipient's T cells recognize foreign antigen processed on the recipient's APCs

Answer 2

A recipient's T cells recognize donor cells as foreign

Question 3

Which of the following are advantages of peripheral blood stem cell transplant over traditional bone marrow transplant?
I. Rapid engraftment
II. Sample collection is easy
III. Higher graft survival rates

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 3

I, II, and III

Question 4

A patient may have pre-existing antibodies to a major or minor HLA antigen caused by:
I- Medication
II- Pregnancy
III- Previous transplant

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Question 5

How is the T cell response during transplant rejection different from the response during an infection?

A) Few T cells are responding during rejection
B) No T cells respond during rejection, only B cells
C) The number of T cells responding is much higher during rejection
D) The same amount of cells respond, but the response is stronger during rejection

Question 6

The main immune response in a case of acute rejection of a transplanted organ is:

A) B cell activation
B) Both B and T cell activation
C) Allospecific T cell activation
D) Attack of organ by pre-existing antibodies

Question 7

Without genetic modification, what is the main cause of rejection in xenotransplants?

A) Transfer of infection
B) Organs are the wrong size
C) The minor HLA antigens do not match
D) Pre-existing antibodies to alpha-galactosyl

Question 8

RD was involved in a car accident and had burns on his right forearm. Doctors removed skin from his leg and grafted it onto his arm. What type of transplant is this?

A) Isograft
B) Allograft
C) Autograft
D) Xenograft

Question 9

One of the steps taken to avoid graft-versus-host disease (GVHD) is:

A) Immunostimulation
B) Matching minor histocompatibility
C) Removing all T cells from the graft
D) Removing all B cells from the graft

Question 10

Which immunosuppressive agent causes redistribution of CD4 T cells from the peripheral blood to the spleen and bone marrow?

A) Corticosteroids
B) Monomurab-CD3
C) Calcineurin inhibitors
D) Antiproliferative agents