Question 1

The main immune response in a case of chronic rejection of a transplanted organ is:

Accepted Answer

A)  B cell activation 
B)  Both B and T cell activation 
C)  Allospecific T cell activation 
D)  Attack of organ by pre-existing antibodies 
A)  B cell activation 
B)  Both B and T cell activation 
C)  Allospecific T cell activation 
D)  Attack of organ by pre-existing antibodies B

Question 2

RD was involved in a car accident and had burns on his right forearm. Doctors removed skin from his leg and grafted it onto his arm. What type of transplant is this?

Accepted Answer

A)  Isograft 
B)  Allograft 
C)  Autograft 
D)  Xenograft 
A)  Isograft 
B)  Allograft 
C)  Autograft 
D)  Xenograft C

Question 3

A patient may have pre-existing antibodies to a major or minor HLA antigen caused by:
I- Medication
II- Pregnancy
III- Previous transplant

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III D

Question 4

Direct antigen presentation occurring during allogeneic graft rejection occurs when:

Accepted Answer

A)  Donor APCs present antigen to the donor T cells 
B)  A recipient's T cells recognize donor cells as foreign 
C)  Donor antibodies bind to recipient cell surface molecules 
D)  A recipient's T cells recognize foreign antigen processed on the recipient's APCs 
A)  Donor APCs present antigen to the donor T cells 
B)  A recipient's T cells recognize donor cells as foreign 
C)  Donor antibodies bind to recipient cell surface molecules 
D)  A recipient's T cells recognize foreign antigen processed on the recipient's APCs

Question 5

The main immune response in a case of acute rejection of a transplanted organ is:

Accepted Answer

A)  B cell activation 
B)  Both B and T cell activation 
C)  Allospecific T cell activation 
D)  Attack of organ by pre-existing antibodies 
A)  B cell activation 
B)  Both B and T cell activation 
C)  Allospecific T cell activation 
D)  Attack of organ by pre-existing antibodies

Question 6

Which immunosuppressive agent causes redistribution of CD4 T cells from the peripheral blood to the spleen and bone marrow?

Accepted Answer

A)  Corticosteroids 
B)  Monomurab-CD3 
C)  Calcineurin inhibitors 
D)  Antiproliferative agents 
A)  Corticosteroids 
B)  Monomurab-CD3 
C)  Calcineurin inhibitors 
D)  Antiproliferative agents

Question 7

One of the steps taken to avoid graft-versus-host disease (GVHD) is:

Accepted Answer

A)  Immunostimulation 
B)  Matching minor histocompatibility 
C)  Removing all T cells from the graft 
D)  Removing all B cells from the graft 
A)  Immunostimulation 
B)  Matching minor histocompatibility 
C)  Removing all T cells from the graft 
D)  Removing all B cells from the graft

Question 8

Without genetic modification, what is the main cause of rejection in xenotransplants?

Accepted Answer

A)  Transfer of infection 
B)  Organs are the wrong size 
C)  The minor HLA antigens do not match 
D)  Pre-existing antibodies to alpha-galactosyl 
A)  Transfer of infection 
B)  Organs are the wrong size 
C)  The minor HLA antigens do not match 
D)  Pre-existing antibodies to alpha-galactosyl

Question 9

How is the T cell response during transplant rejection different from the response during an infection?

Accepted Answer

A)  Few T cells are responding during rejection 
B)  No T cells respond during rejection, only B cells 
C)  The number of T cells responding is much higher during rejection 
D)  The same amount of cells respond, but the response is stronger during rejection 
A)  Few T cells are responding during rejection 
B)  No T cells respond during rejection, only B cells 
C)  The number of T cells responding is much higher during rejection 
D)  The same amount of cells respond, but the response is stronger during rejection

Question 10

Which of the following are advantages of peripheral blood stem cell transplant over traditional bone marrow transplant? 
I. Rapid engraftment
II. Sample collection is easy
III. Higher graft survival rates

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

The main immune response in a case of chronic rejection of a transplanted organ is:

RD was involved in a car accident and had burns on his right forearm. Doctors removed skin from his leg and grafted it onto his arm. What type of transplant is this?

A patient may have pre-existing antibodies to a major or minor HLA antigen caused by: I- Medication II- Pregnancy III- Previous transplant

Direct antigen presentation occurring during allogeneic graft rejection occurs when:

The main immune response in a case of acute rejection of a transplanted organ is:

Which immunosuppressive agent causes redistribution of CD4 T cells from the peripheral blood to the spleen and bone marrow?

One of the steps taken to avoid graft-versus-host disease (GVHD) is:

Without genetic modification, what is the main cause of rejection in xenotransplants?

How is the T cell response during transplant rejection different from the response during an infection?

Which of the following are advantages of peripheral blood stem cell transplant over traditional bone marrow transplant? I. Rapid engraftment II. Sample collection is easy III. Higher graft survival rates

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

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Exam 17: Transplantation

The main immune response in a case of chronic rejection of a transplanted organ is:

RD was involved in a car accident and had burns on his right forearm. Doctors removed skin from his leg and grafted it onto his arm. What type of transplant is this?

A patient may have pre-existing antibodies to a major or minor HLA antigen caused by: I- Medication II- Pregnancy III- Previous transplant

Direct antigen presentation occurring during allogeneic graft rejection occurs when:

The main immune response in a case of acute rejection of a transplanted organ is:

Which immunosuppressive agent causes redistribution of CD4 T cells from the peripheral blood to the spleen and bone marrow?

One of the steps taken to avoid graft-versus-host disease (GVHD) is:

Without genetic modification, what is the main cause of rejection in xenotransplants?

How is the T cell response during transplant rejection different from the response during an infection?

Which of the following are advantages of peripheral blood stem cell transplant over traditional bone marrow transplant? I. Rapid engraftment II. Sample collection is easy III. Higher graft survival rates

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters