Deck 20: Cytotoxic T Cells

Question 1

Tumor infiltrating lymphocytes (TILs) found in a solid tumor or melanoma may indicate:

A) A good prognosis due to small tumor size
B) A bad prognosis due to an aggressive cancer
C) A good prognosis due to a vigorous immune response
D) A bad prognosis due to damage to surrounding tissue by the immune system

Answer 1

A good prognosis due to a vigorous immune response

Question 2

Which molecules are required to stabilize the interaction between CD8 T cells and antigen presenting cells (APCs) that leads to activation of the CTLs?

A) Fas and FasL
B) CD28 and B7-1
C) TNF and TNF receptor 1 (TNFRI)
D) CD2 and lymphocyte function-associated antigen-1 (LFA-1)

Answer 2

CD28 and B7-1

Question 3

Which of the following is a method that viruses use to evade the immune system?

A) Mutation of hemagglutinin
B) Upregulation of TAP molecules
C) Prevention of MHC class II expression
D) Increased production of transforming growth factor-b (TGF-b)

Answer 3

Mutation of hemagglutinin

Question 4

What role does perforin perform in the death of target cells?

A) Perforin activates caspases.
B) Perforin creates a pore in the host cell.
C) Perforin disrupts mitochondrial function.
D) Perforin cleaves and activates granzymes.

Question 5

The main immunological defect in familial erythrophagocytic lymphohistiocytosis type 2 is:

A) Inability to synthesize perforin
B) Production of nonfunctional granzymes
C) Inability to secrete perforin and granzymes
D) Production of reduced amounts of cathepsin C

Question 6

Patients have a high risk of losing all of their teeth due which disease?

A) Melanoma
B) Papillion-Lefèvre syndrome
C) Autoimmune lymphoproliferative syndrome type 2
D) Familial erythrophagocytic lymphohistiocytosis type 2

Question 7

When a CTL with FasL interacts with a target cell possessing Fas, what happens to the target cell?

A) The target cell dies via apoptotic cell death.
B) Nothing; the target cell is healthy and remains intact.
C) The target cell goes into cell cycle arrest and repairs damage.
D) Nothing, but the interaction with the target cell causes death of the CTL.

Question 8

Which of the following is a method that tumors use to evade the immune response?

A) Producing IL-2 analogs
B) Reducing TAP function
C) Upregulating MHC class I molecules
D) Engaging Fas receptors on T cells to cause T cell death

Question 9

Cytotoxic (CD8+) T cells (CTLs) are activated by:

A) Antigen presented on MHC class I molecules
B) Antigen presented on MHC class II molecules
C) Antigen presented on MHC class I or II molecules
D) CTLs do not require activation to kill

Question 10

Which of the following cells may contain perforin and granzymes?
I. Tumor cells
II. CD4 T cells
III. CD8 T cells

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III