Question 1

The main immunological defect in familial erythrophagocytic lymphohistiocytosis type 2 is:

Accepted Answer

A)  Inability to synthesize perforin 
B)  Production of nonfunctional granzymes 
C)  Inability to secrete perforin and granzymes 
D)  Production of reduced amounts of cathepsin C 
A)  Inability to synthesize perforin 
B)  Production of nonfunctional granzymes 
C)  Inability to secrete perforin and granzymes 
D)  Production of reduced amounts of cathepsin C C

Question 2

When a CTL with FasL interacts with a target cell possessing Fas, what happens to the target cell?

Accepted Answer

A)  The target cell dies via apoptotic cell death. 
B)  Nothing; the target cell is healthy and remains intact. 
C)  The target cell goes into cell cycle arrest and repairs damage. 
D)  Nothing, but the interaction with the target cell causes death of the CTL. 
A)  The target cell dies via apoptotic cell death. 
B)  Nothing; the target cell is healthy and remains intact. 
C)  The target cell goes into cell cycle arrest and repairs damage. 
D)  Nothing, but the interaction with the target cell causes death of the CTL. A

Question 3

Cytotoxic (CD8+) T cells (CTLs) are activated by:

Accepted Answer

A)  Antigen presented on MHC class I molecules 
B)  Antigen presented on MHC class II molecules 
C)  Antigen presented on MHC class I or II molecules 
D)  CTLs do not require activation to kill 
A)  Antigen presented on MHC class I molecules 
B)  Antigen presented on MHC class II molecules 
C)  Antigen presented on MHC class I or II molecules 
D)  CTLs do not require activation to kill A

Question 4

Patients have a high risk of losing all of their teeth due which disease?

Accepted Answer

A)  Melanoma 
B)  Papillion-Lefèvre syndrome 
C)  Autoimmune lymphoproliferative syndrome type 2 
D)  Familial erythrophagocytic lymphohistiocytosis type 2 
A)  Melanoma 
B)  Papillion-Lefèvre syndrome 
C)  Autoimmune lymphoproliferative syndrome type 2 
D)  Familial erythrophagocytic lymphohistiocytosis type 2

Question 5

What role does perforin perform in the death of target cells?

Accepted Answer

A)  Perforin activates caspases. 
B)  Perforin creates a pore in the host cell. 
C)  Perforin disrupts mitochondrial function. 
D)  Perforin cleaves and activates granzymes. 
A)  Perforin activates caspases. 
B)  Perforin creates a pore in the host cell. 
C)  Perforin disrupts mitochondrial function. 
D)  Perforin cleaves and activates granzymes.

Question 6

Which of the following is a method that tumors use to evade the immune response?

Accepted Answer

A)  Producing IL-2 analogs 
B)  Reducing TAP function 
C)  Upregulating MHC class I molecules 
D)  Engaging Fas receptors on T cells to cause T cell death 
A)  Producing IL-2 analogs 
B)  Reducing TAP function 
C)  Upregulating MHC class I molecules 
D)  Engaging Fas receptors on T cells to cause T cell death

Question 7

Tumor infiltrating lymphocytes (TILs) found in a solid tumor or melanoma may indicate:

Accepted Answer

A)  A good prognosis due to small tumor size 
B)  A bad prognosis due to an aggressive cancer 
C)  A good prognosis due to a vigorous immune response 
D)  A bad prognosis due to damage to surrounding tissue by the immune system 
A)  A good prognosis due to small tumor size 
B)  A bad prognosis due to an aggressive cancer 
C)  A good prognosis due to a vigorous immune response 
D)  A bad prognosis due to damage to surrounding tissue by the immune system

Question 8

Which of the following is a method that viruses use to evade the immune system?

Accepted Answer

A)  Mutation of hemagglutinin 
B)  Upregulation of TAP molecules 
C)  Prevention of MHC class II expression 
D)  Increased production of transforming growth factor-b (TGF-b) 
A)  Mutation of hemagglutinin 
B)  Upregulation of TAP molecules 
C)  Prevention of MHC class II expression 
D)  Increased production of transforming growth factor-b (TGF-b)

Question 9

Which of the following cells may contain perforin and granzymes? 
I. Tumor cells
II. CD4 T cells
III. CD8 T cells

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Question 10

Which molecules are required to stabilize the interaction between CD8 T cells and antigen presenting cells (APCs) that leads to activation of the CTLs?

Accepted Answer

A)  Fas and FasL 
B)  CD28 and B7-1 
C)  TNF and TNF receptor 1 (TNFRI) 
D)  CD2 and lymphocyte function-associated antigen-1 (LFA-1) 
A)  Fas and FasL 
B)  CD28 and B7-1 
C)  TNF and TNF receptor 1 (TNFRI) 
D)  CD2 and lymphocyte function-associated antigen-1 (LFA-1)

The main immunological defect in familial erythrophagocytic lymphohistiocytosis type 2 is:

When a CTL with FasL interacts with a target cell possessing Fas, what happens to the target cell?

Cytotoxic (CD8+) T cells (CTLs) are activated by:

Patients have a high risk of losing all of their teeth due which disease?

What role does perforin perform in the death of target cells?

Which of the following is a method that tumors use to evade the immune response?

Tumor infiltrating lymphocytes (TILs) found in a solid tumor or melanoma may indicate:

Which of the following is a method that viruses use to evade the immune system?

Which of the following cells may contain perforin and granzymes? I. Tumor cells II. CD4 T cells III. CD8 T cells

Which molecules are required to stabilize the interaction between CD8 T cells and antigen presenting cells (APCs) that leads to activation of the CTLs?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 20: Cytotoxic T Cells

The main immunological defect in familial erythrophagocytic lymphohistiocytosis type 2 is:

When a CTL with FasL interacts with a target cell possessing Fas, what happens to the target cell?

Cytotoxic (CD8+) T cells (CTLs) are activated by:

Patients have a high risk of losing all of their teeth due which disease?

What role does perforin perform in the death of target cells?

Which of the following is a method that tumors use to evade the immune response?

Tumor infiltrating lymphocytes (TILs) found in a solid tumor or melanoma may indicate:

Which of the following is a method that viruses use to evade the immune system?

Which of the following cells may contain perforin and granzymes? I. Tumor cells II. CD4 T cells III. CD8 T cells

Which molecules are required to stabilize the interaction between CD8 T cells and antigen presenting cells (APCs) that leads to activation of the CTLs?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters