Deck 21: Natural Killer Cells

Question 1

NKT cells require antigen presentation by:
I- CD1
II- MHC class I molecules
III- MHC class II molecules

A) I only
B) III only
C) I and II
D) II and III
E) I, II, and III

Answer 1

I only

Question 2

NK cells produce which cytokine that activates macrophages?

A) IL-1
B) IL-13
C) TNF-a
D) Interferon-g

Answer 2

Interferon-g

Question 3

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

A) The increased production of IL-13
B) Increased numbers of NKT type I cells
C) The inability to kill through the perforin and granzymes pathway
D) The inability to produce activating and inhibiting receptors in the NK cell surface

Answer 3

The inability to kill through the perforin and granzymes pathway

Question 4

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

A) NK CD56dim cells
B) NK CD56bright cells
C) NKT type I cells
D) NKT type II cells

Question 5

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

A) T cell
B) B cell
C) NK cell
D) Neutrophil

Question 6

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC)?

A) CD3
B) CD16
C) CD56
D) CD94

Question 7

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

A) cAMP
B) Kinase
C) ATPase
D) Phosphatase

Question 8

Which cell type can kill target cells using the perforin and granzymes method?

A) NKT type I cells
B) NKT type II cells
C) NK CD56dim cells
D) NK CD56bright cells

Question 9

Which of the following is true concerning natural killer (NK) cells?

A) NK cells never express CD16.
B) NK cells never express CD56.
C) NK cells express both B and T cell markers.
D) NK cells do not express B or T cell markers.

Question 10

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

A) The host cell will not be killed because the NK cell needs two different activating signals to kill a host cell.
B) The host cell will not be killed because the MHC class I molecules cause inhibition that overrides the activating signals.
C) The host cell will be killed because the NK cell does not bind MHC class I molecules and the activating signal causes cell death.
D) The host cell will be killed because the activating signal overrides the inhibitory signal caused by the MHC class I molecule binding.