Question 1

Which of the following is true concerning natural killer (NK) cells?

Accepted Answer

A)  NK cells never express CD16. 
B)  NK cells never express CD56. 
C)  NK cells express both B and T cell markers. 
D)  NK cells do not express B or T cell markers. 
A)  NK cells never express CD16. 
B)  NK cells never express CD56. 
C)  NK cells express both B and T cell markers. 
D)  NK cells do not express B or T cell markers. D

Question 2

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

Accepted Answer

A)  cAMP 
B)  Kinase 
C)  ATPase 
D)  Phosphatase 
A)  cAMP 
B)  Kinase 
C)  ATPase 
D)  Phosphatase D

Question 3

NK cells produce which cytokine that activates macrophages?

Accepted Answer

A)  IL-1 
B)  IL-13 
C)  TNF-a 
D)  Interferon-g 
A)  IL-1 
B)  IL-13 
C)  TNF-a 
D)  Interferon-g D

Question 4

Which cell type can kill target cells using the perforin and granzymes method?

Accepted Answer

A)  NKT type I cells 
B)  NKT type II cells 
C)  NK CD56dim cells 
D)  NK CD56bright cells 
A)  NKT type I cells 
B)  NKT type II cells 
C)  NK CD56dim cells 
D)  NK CD56bright cells

Question 5

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Accepted Answer

A)  T cell 
B)  B cell 
C)  NK cell 
D)  Neutrophil 
A)  T cell 
B)  B cell 
C)  NK cell 
D)  Neutrophil

Question 6

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

Accepted Answer

A)  NK CD56dim cells 
B)  NK CD56bright cells 
C)  NKT type I cells 
D)  NKT type II cells 
A)  NK CD56dim cells 
B)  NK CD56bright cells 
C)  NKT type I cells 
D)  NKT type II cells

Question 7

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Accepted Answer

A)  The host cell will not be killed because the NK cell needs two different activating signals to kill a host cell. 
B)  The host cell will not be killed because the MHC class I molecules cause inhibition that overrides the activating signals. 
C)  The host cell will be killed because the NK cell does not bind MHC class I molecules and the activating signal causes cell death. 
D)  The host cell will be killed because the activating signal overrides the inhibitory signal caused by the MHC class I molecule binding. 
A)  The host cell will not be killed because the NK cell needs two different activating signals to kill a host cell. 
B)  The host cell will not be killed because the MHC class I molecules cause inhibition that overrides the activating signals. 
C)  The host cell will be killed because the NK cell does not bind MHC class I molecules and the activating signal causes cell death. 
D)  The host cell will be killed because the activating signal overrides the inhibitory signal caused by the MHC class I molecule binding.

Question 8

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Accepted Answer

A)  The increased production of IL-13 
B)  Increased numbers of NKT type I cells 
C)  The inability to kill through the perforin and granzymes pathway 
D)  The inability to produce activating and inhibiting receptors in the NK cell surface 
A)  The increased production of IL-13 
B)  Increased numbers of NKT type I cells 
C)  The inability to kill through the perforin and granzymes pathway 
D)  The inability to produce activating and inhibiting receptors in the NK cell surface

Question 9

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC)?

Accepted Answer

A)  CD3 
B)  CD16 
C)  CD56 
D)  CD94 
A)  CD3 
B)  CD16 
C)  CD56 
D)  CD94

Question 10

NKT cells require antigen presentation by:
I- CD1
II- MHC class I molecules
III- MHC class II molecules

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Which of the following is true concerning natural killer (NK) cells?

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

NK cells produce which cytokine that activates macrophages?

Which cell type can kill target cells using the perforin and granzymes method?

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC)?

NKT cells require antigen presentation by: I- CD1 II- MHC class I molecules III- MHC class II molecules

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

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Exam 21: Natural Killer Cells

Which of the following is true concerning natural killer (NK) cells?

NK cells have cell surface receptors that contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which bind ligand and recruit which type of molecule to transmit the inhibitory signal?

NK cells produce which cytokine that activates macrophages?

Which cell type can kill target cells using the perforin and granzymes method?

A host cell that has been infected with the influenza virus and has subsequently downregulated MHC class I molecules is most likely to be recognized by which cell type?

Which of the following cell types may play a role in allergic reactions, particularly in relation to asthma?

If a host cell expresses both MHC class I molecules and ligands that bind activating receptors on NK cells, what is the outcome for the host cell?

Individuals with Chediak-Higashi syndrome have a genetic defect that causes:

Which is the main surface molecule on NK cells that is involved in antibody-dependent cell-mediated cytotoxicity (ADCC)?

NKT cells require antigen presentation by: I- CD1 II- MHC class I molecules III- MHC class II molecules

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters