Deck 20: Development of the Eyes

Question 1

What are the key protein constituent(s)of the lens?

A) Melanin
B) Crystallins
C) Keratins

Answer 1

B

Question 2

Which is the most frequent genetic syndrome that affects the retina?

A) Osteoporosis-pseudoglioma syndrome
B) Leber congenital amaurosis syndrome
C) Retinitis pigmentosa
D) Familial exudative vitreoretinopathy
E) Norrie disease

Answer 2

B

Question 3

Protanopes lack which cell type?

A) S cones
B) M cones
C) L cones
D) Rods

Answer 3

C

Question 4

Researchers have shown that the various regions of the developing eye are specified by different transcription factors whose expression is induced by the adjacent tissues.Which region of the eye requires the transcription factor Chx10?

A) Optic stalk
B) Neural retina
C) Pigmented retina
D) Lens
E) Cornea

Question 5

Goldenhar syndrome is characterized by a spectrum of defects.What eye abnormality is the cardinal finding of this syndrome?

A) Epicanthal folds
B) Cryptophthalmos
C) Epibulbar dermoids
D) Distichiasis
E) Ocular telangiectasia

Question 6

Researchers have shown that the various regions of the developing eye are specified by different transcription factors whose expression is induced by the adjacent tissues.Chx10 is one such factor that is required for the development of the neural retina.What growth factor regulates its expression?

A) Shh
B) TgfBeta
C) Fgf
D) Egf
E) Vegf

Question 7

Branchio-oto-renal syndrome,characterized by kidney and hearing defects,is due to mutation of which gene?

A) EYES ABSENT HOMOLOG 1(EYA1)
B) EYES ABSENT HOMOLOG 4 (EYA4)
C) POU4F3
D) CONNEXIN 26
E) FGF8

Question 8

Mutations in the gene encoding the FOXC2 transcription factor would be expected to cause which anomaly?

A) Epicanthal folds
B) Cryptophthalmos
C) Epibulbar dermoids
D) Distichiasis
E) Ocular telangiectasia

Question 9

Coloboma results from failure of which development event?

A) Eye induction
B) Differentiation of the photoreceptors
C) Regression of the hyaloid artery
D) Closure of the optic fissure
E) Formation of the eyelids

Question 10

Which growth factor signaling pathway initiates retinal differentiation in the fovea?

A) Shh
B) Wnt
C) Notch
D) Bmp
E) Fgf

Question 11

During retinal differentiation,the various cell types differentiate in sequence.Which cell type is the last to be born?

A) Müller
B) Ganglion
C) Amacrine
D) Bipolar
E) Rod
F) Cone