Deck 2: Altered Cellular and Tissue Biology

Question 1

What mechanisms occur in the liver cells as a result of lipid accumulation?

A) Accumulation of lipids that obstruct the common bile duct, preventing flow of bile from the liver to the gallbladder
B) Increased synthesis of triglycerides from fatty acids and decreased synthesis of apoproteins
C) Increased binding of lipids with apoproteins to form lipoproteins
D) Increased conversion of fatty acids to phospholipids

Answer 1

Increased synthesis of triglycerides from fatty acids and decreased synthesis of apoproteins

Question 2

Acute alcoholism mainly affects which body system?

A) Hepatic
B) Gastrointestinal
C) Renal
D) Central nervous

Answer 2

Central nervous

Question 3

Which statement is a description of the characteristics of apoptosis?

A) Programmed cell death of scattered, single cells
B) Characterized by swelling of the nucleus and cytoplasm
C) Unpredictable patterns of cell death
D) Results in benign malignancies

Answer 3

Programmed cell death of scattered, single cells

Question 4

The loss of the adenosine triphosphate (ATP)during ischemia causes cells to:

A) Shrink because of the influx of calcium (Ca).
B) Shrink because of the influx of potassium chloride (KCl).
C) Swell because of the influx of sodium chloride (NaCl).
D) Swell because of the influx of nitric oxide (NO).

Question 5

The mammary glands enlarge during pregnancy primarily as a consequence of hormonal:

A) Atrophy
B) Hyperplasia
C) Anaplasia
D) Dysplasia

Question 6

Free radicals cause cell damage by:

A) Stealing the cell's oxygen to stabilize the electron, thus causing hypoxia
B) Stimulating the release of lysosomal enzymes that digest the cell membranes
C) Transferring one of its charged, stabilized atoms to the cell membrane, which causes lysis
D) Giving up an electron, which causes injury to the chemical bonds of the cell membrane

Question 7

Free radicals play a major role in the initiation and progression of which diseases?

A) Cardiovascular diseases such as hypertension and ischemic heart disease
B) Renal diseases such as acute tubular necrosis and glomerulonephritis
C) Gastrointestinal diseases such as peptic ulcer disease and Crohn disease
D) Muscular disease such as muscular dystrophy and fibromyalgia

Question 8

What physiologic change occurs during heat exhaustion?

A) Hemoconcentration occurs because of the loss of salt and water.
B) Cramping of voluntary muscles occurs as a result of salt loss.
C) Thermoregulation fails because of high core temperatures.
D) Subcutaneous layers are damaged because of high core temperatures.

Question 9

Which statement is true regarding the difference between subdural hematoma and epidural hematoma?

A) No difference exists, and these terms may be correctly used interchangeably.
B) A subdural hematoma occurs above the dura, whereas an epidural hematoma occurs under the dura.
C) A subdural hematoma is often the result of shaken baby syndrome, whereas an epidural hematoma rapidly forms as a result of a skull fracture.
D) A subdural hematoma usually forms from bleeding within the skull, such as an aneurysm eruption, whereas an epidural hematoma occurs from trauma outside the skull, such as a blunt force trauma.

Question 10

Hemoprotein accumulations are a result of the excessive storage of:

A) Iron, which is transferred from the cells to the bloodstream
B) Hemoglobin, which is transferred from the bloodstream to the cells
C) Albumin, which is transferred from the cells to the bloodstream
D) Amino acids, which are transferred from the cells to the bloodstream

Question 11

What is a consequence of leakage of lysosomal enzymes during chemical injury?

A) Enzymatic digestion of the nucleus and nucleolus occurs, halting DNA synthesis.
B) Influx of potassium ions into the mitochondria occurs, halting the ATP production.
C) Edema of the Golgi body occurs, preventing the transport of proteins out of the cell.
D) Shift of calcium out of the plasma membrane occurs, destroying the cytoskeleton.

Question 12

Lead causes damage within the cell by interfering with the action of:

A) Sodium and chloride
B) Potassium
C) Calcium
D) ATP

Question 13

Which type of cell adaptation occurs when normal columnar ciliated epithelial cells of the bronchial lining have been replaced by stratified squamous epithelial cells?

A) Hyperplasia
B) Metaplasia
C) Dysplasia
D) Anaplasia

Question 14

Carbon monoxide causes tissue damage by:

A) Competing with carbon dioxide so that it cannot be excreted
B) Binding to hemoglobin so that it cannot carry oxygen
C) Destroying the chemical bonds of hemoglobin so it cannot carry oxygen
D) Removing iron from hemoglobin so it cannot carry oxygen

Question 15

What is the most common site of lipid accumulation?

A) Coronary arteries
B) Kidneys
C) Liver
D) Subcutaneous tissue

Question 16

What is a consequence of plasma membrane damage to the mitochondria?

A) Enzymatic digestion halts DNA synthesis.
B) Influx of calcium ions halts ATP production.
C) Edema from an influx in sodium causes a reduction in ATP production.
D) Potassium shifts out of the mitochondria, which destroys the infrastructure.

Question 17

Lead poisoning affects the nervous system by:

A) Interfering with the function of neurotransmitters
B) Inhibiting the production of myelin around nerves
C) Increasing the resting membrane potential
D) Altering the transport of potassium into the nerves

Question 18

In hypoxic injury,sodium enters the cell and causes swelling because:

A) The cell membrane permeability increases for sodium during periods of hypoxia.
B) ATP is insufficient to maintain the pump that keeps sodium out of the cell.
C) The lactic acid produced by the hypoxia binds with sodium in the cell.
D) Sodium cannot be transported to the cell membrane during hypoxia.

Question 19

Hemosiderosis is a condition that results in the excess of what substance being stored as hemosiderin in cells of many organs and tissues?

A) Hemoglobin
B) Ferritin
C) Iron
D) Transferrin

Question 20

During cell injury caused by hypoxia,an increase in the osmotic pressure occurs within the cell because:

A) Plasma proteins enter the cell.
B) The adenosine triphosphatase (ATPase)-driven pump is stronger during hypoxia.
C) Sodium chloride enters the cell.
D) An influx of glucose occurs through the injured cell membranes.

Question 21

What organs are affected by the type of necrosis that results from either severe ischemia or chemical injury? (Select all that apply.)

A) Lungs
B) Brain
C) Kidneys
D) Muscles
E) Heart

Question 22

During cell injury caused by hypoxia,sodium and water move into the cell because:

A) Potassium moves out of the cell, and potassium and sodium are inversely related.
B) The pump that transports sodium out of the cell cannot function because of a decrease in ATP levels.
C) The osmotic pressure is increased, which pulls additional sodium across the cell membrane.
D) Oxygen is not available to bind with sodium to maintain it outside of the cell.

Question 23

What is the cause of free calcium in the cytosol that damages cell membranes by uncontrolled enzyme activation?

A) Activation of endonuclease interferes with the binding of calcium to protein.
B) Activation of phospholipases, to which calcium normally binds, degrades the proteins.
C) An influx of phosphate ions competes with calcium for binding to proteins.
D) Depletion of ATP normally pumps calcium from the cell.

Question 24

What type of necrosis is often associated with pulmonary tuberculosis?

A) Bacteriologic
B) Caseous
C) Liquefactive
D) Gangrenous

Question 25

It is true that nondividing cells are:

A) Found in gastrointestinal lining
B) Affected by hyperplasia
C) Incapable of synthesizing DNA
D) Affected by only hypertrophy

Question 26

After ovulation,the uterine endometrial cells divide under the influence of estrogen.This process is an example of hormonal:

A) Hyperplasia
B) Dysplasia
C) Hypertrophy
D) Anaplasia

Question 27

Which organs are affected by lead consumption? (Select all that apply.)

A) Bones
B) Muscles
C) Pancreas
D) Nerves
E) Eyes

Question 28

What two types of hearing loss are associated with noise?

A) Acoustic trauma and noise-induced
B) High frequency and low frequency
C) High frequency and acoustic trauma
D) Noise-induced and low frequency

Question 29

The abnormal proliferation of cells in response to excessive hormonal stimulation is called:

A) Dysplasia
B) Pathologic dysplasia
C) Hyperplasia
D) Pathologic hyperplasia

Question 30

What is an example of compensatory hyperplasia?

A) Hepatic cells increase cell division after part of the liver is excised.
B) Skeletal muscle cells atrophy as a result of paralysis.
C) The heart muscle enlarges as a result of hypertension.
D) The size of the uterus increases during pregnancy.

Question 31

In decompression sickness,emboli are formed by bubbles of:

A) Oxygen
B) Nitrogen
C) Carbon monoxide
D) Hydrogen

Question 32

Which is an effect of ionizing radiation exposure?

A) Respiratory distress
B) Sun intolerance
C) DNA aberrations
D) Death

Question 33

Current research has determined that chemical-induced cellular injury:

A) Affects the permeability of the plasma membrane.
B) Is often the result of the damage caused by reactive free radicals.
C) Is rarely influenced by lipid peroxidation.
D) Seldom involves the cell's organelles.

Question 34

What is the single most common cause of cellular injury?

A) Hypoxic injury
B) Chemical injury
C) Infectious injury
D) Genetic injury

Question 35

What type of necrosis results from ischemia of neurons and glial cells?

A) Coagulative
B) Liquefactive
C) Caseous
D) Gangrene

Question 36

What effect does fetal alcohol syndrome have on newborns? (Select all that apply.)

A) Failure of alveoli to open
B) Cognitive impairment
C) Incompetent semilunar values
D) Esophageal stricture
E) Facial anomalies

Question 37

Removal of part of the liver leads to the remaining liver cells undergoing compensatory:

A) Atrophy
B) Metaplasia
C) Hyperplasia
D) Dysplasia

Question 38

Current research supports the believe that,after heart muscle injury,the damage:

A) Remains indefinitely because cardiac cells do not reproduce.
B) Is repaired by newly matured cardiomyocytes.
C) Gradually decreases in size as mitotic cell division occurs.
D) Is replaced by hypertrophy of remaining cells.

Question 39

What type of necrosis is associated with wet gangrene?

A) Coagulative
B) Liquefactive
C) Caseous
D) Gangrene

Question 40

Dysplasia refers to a(n):

A) Abnormal increase in the number of a specific cell type
B) True adaptive process at the cellular level
C) Modification in the shape of a specific cell type
D) Lack of oxygen at the cellular level

Question 41

Which statements are true regarding the effects of marijuana use? (Select all that apply.)

A) Smoking the drug results in greater absorption that eating it.
B) Heavy use can result in psychomotor impairments.
C) Smoking four "joints" a day equals smoking approximately 20 cigarettes.
D) Research does not support marijuana use as a factor in developing lung cancer.
E) Fetal development appears to be unharmed by marijuana use.

Question 42

Examples of adaptive cellular responses include: (Select all that apply.)

A) Atrophy
B) Dysplasia
C) Hypertrophy
D) Hyperplasia
E) Metaplasia

Question 43

Blunt force injuries would include a: (Select all that apply.)

A) Bruise to the upper arm, resulting from a fall
B) Simple tibia fracture sustained in a skiing accident
C) Cut on the finger while slicing vegetables for a salad
D) Spleen laceration caused by a punch during a physical fight
E) Small caliber gunshot wound to the foot while target shooting

Question 44

It is true that melanin is: (Select all that apply.)

A) Rarely found in epithelial cells
B) Found in cells called keratinocytes, which are present in the retina
C) A factor in the prevention of certain types of cancer
D) Most influential in managing the effects of short-term sunlight exposure
E) Accumulated in specific cells found in the skin