Deck 5: Cytokines

Question 1

Cytokines exhibit pleiotropy,which refers to:

A) multiple cytokines affecting the same cell
B) one cytokine inhibiting the activity of another cytokine
C) one cytokine affecting multiple cells
D) cytokines acting together to affect a cell

Answer 1

one cytokine affecting multiple cells

Question 2

When multiple cytokines act on the same cell,by definition they have:

A) pleiotropy
B) redundancy
C) synergism
D) antagonism

Answer 2

redundancy

Question 3

Which cytokine is involved in natural immunity?

A) interleukin-6
B) interleukin-2
C) interleukin-4
D) interleukin-5

Answer 3

interleukin-6

Question 4

The actions of IL-1 and IL-10 are an example of:

A) redundancy
B) antagonism
C) synergy
D) pleiotropy

Question 5

The main target of interleukin-3 is:

A) antigen-activated B cells
B) antigen-activated T cells
C) macrophages
D) stem cells

Question 6

A cytokine that is produced by TH2 cells and inhibits TH1 cells is:

A) IL-10
B) IL-4
C) IL-3
D) IFN-gamma

Question 7

When Il-2 acts on T cells,B cells,and NK cells,this is an example of:

A) redundancy
B) pleiotropy
C) synergy
D) antagonism

Question 8

IL-1,IL-6,and tumor necrosis factor-alpha function by:

A) increasing vascular permeability
B) increasing acute phase proteins
C) acting on the hypothalamus
D) promoting migration of inflammatory cells
E) all of these

Question 9

IL-4 functions by:

A) inhibiting macrophages
B) inducing hematopoiesis
C) activating B cells
D) activating macrophages

Question 10

IL-3,IL-7,and GM-CSF are all involved in:

A) hematopoiesis
B) suppressing inflammation
C) macrophage killing
D) T cell cytotoxicity

Question 11

IL-2 is produced by one cell and the same IL-2 stimulates that same cell.This type of cytokine activity is called:

A) autocrine
B) paracrine
C) endocrine
D) pleotropic

Question 12

IFN-gamma is produced by:

A) B cells
B) TH1 cells
C) TH2 cells
D) macrophages

Question 13

A protein released from a virally infected cell that protects other cells from viral invasion best describes:

A) Il-3
B) interferon-alpha
C) TNF
D) IL-4

Question 14

What is the main function of chemokines?

A) inhibit the immune response
B) enhance synthesis of acute phase reactants
C) enhance migration of white blood cells
D) protect cells from viral invasion.

Question 15

IL-2 is a cytokine that could be more specifically called which of the following because of the cells that produce it?

A) lymphokine
B) monokine
C) basokine
D) eokine

Question 16

Which of the following cytokines is produced by TH1 cells and is suppressive for TH2 lymphocytes?

A) IL-2
B) IL-4
C) TGF-beta
D) IFN-gamma

Question 17

What is the main action of interferon-gamma?

A) increased synthesis of acute phase reactants
B) stimulation of T cells
C) inhibition of T cell activity
D) activation of macrophages

Question 18

All of the following are actions of interleukin-1 EXCEPT:

A) increased synthesis of acute phase reactants
B) attraction of white cells to the area
C) increased production of IgE
D) acts as an endogenous pyrogen

Question 19

IL-2 is synthesized by which type of cell and acts on which type of cell?

A) TH1; CTL
B) TH2; CTL
C) TH2; NK
D) TH1; mast cells

Question 20

What is the function of TGF- $\beta$ ?

A) helps in antibody-mediated immunity
B) regulates cell growth and differentiation
C) inhibits IL-2
D) acts as an endogenous pyrogen

Question 21

What is one of the main activities of interleukin-4 (IL-4)?

A) downregulation of the immune response
B) increased production of neutrophils
C) generation of TH2 cells
D) protecting cells from viral invasion

Question 22

Which cells produce interleukin-1?

A) T helper cells
B) cytotoxic T cells
C) B cells
D) macrophages

Question 23

Which acts as the best defense against gram-negative bacteria?

A) IL-1
B) TNF
C) IL-2
D) IL-5

Question 24

Which best describes the nature of interleukin-2?

A) activates T helper cells
B) made by macrophages
C) causes lysis of tumor cells
D) down-regulates the immune response

Question 25

Erythropoietin is classified as which of the following?

A) T-cell regulator
B) colony-stimulating factor
C) proinflammatory cytokine
D) regulator of the acute phase response

Question 26

Which of the following can be attributed to interleukin-6 (IL-6)?

A) stimulates red blood cell production
B) increases vascular permeability
C) inhibits antigen presentation by macrophages
D) increases activation of T and B cells