Deck 15: Immunoproliferative Diseases

Question 1

A 55-year-old male presents with symptoms that include weakness,loss of appetite,and anemia.Immunofixation electrophoresis reveals a heavy IgM band.Which of the following is the most likely diagnosis?

A) SCID
B) multiple myeloma
C) Waldenström's macroglobulinemia
D) DiGeorge syndrome

Answer 1

Waldenström's macroglobulinemia

Question 2

What is the main difference between leukemias and lymphomas?

A) In leukemias,malignant cells are mainly located in the tissues.
B) Lymphomas are present mainly in peripheral blood.
C) Lymphomas arise due to a lack of response to stimulating antigens.
D) Lymphomas arise mainly in lymph nodes,the spleen,or other lymphoid tissue.

Answer 2

Lymphomas arise mainly in lymph nodes,the spleen,or other lymphoid tissue.

Question 3

What is the interpretation of the following patient results? (normal values)WBC = 90.0 th/uL (5.0-10.0 th/uL,),with 89% lymphs (20-40%); CD3 = 90% (60-80%); CD5 = 87% (60-80%); CD10 = 0% (< 1%); CD4 = 88% (30-65%); CD20 = 12% (5-20%); CD34 = 0% (< 1%); CD8 = 3% (10-40%); kappa = 10% (3-15%); lambda = 5% (2-10%); CD19 = 15% (5-20%).

A) normal
B) B-cell acute leukemia
C) T-cell acute leukemia
D) B-cell chronic leukemia
E) T-cell chronic leukemia

Answer 3

T-cell chronic leukemia

Question 4

Which immunoproliferative disorder is a cancer of the plasma cells and results in secretion of light chains into the urine?

A) multiple myeloma
B) Waldenström's macroglobulinemia
C) alpha heavy chain disease
D) DiGeorge syndrome

Question 5

What is the interpretation of the following patient results? (normal values)WBC = 25.0 th/uL (5.0-10.0 th/uL),with 78% blasts; CD3 = 83% (60-80%); CD5 = 90% (60-80%); CD10 = 2% (< 1%); CD4 = 85% (30-65%); CD20 = 1% (5-20%); CD34 = 0% (< 1%); CD8 = 87% (10-40%); kappa = 1% (3-15%); lambda = 0% (2-10%); CD19 = 2% (5-20%).

A) normal
B) B-cell acute leukemia
C) T-cell acute leukemia
D) B-cell chronic leukemia
E) T-cell chronic leukemia

Question 6

Which best describes the difference between chronic and acute lymphocytic leukemias?

A) Chronic lymphocytic leukemias are exclusive of T-cell origin.
B) Acute lymphocytic leukemias have a high response rate to chemotherapy.
C) Chronic lymphocytic leukemias have a shorter survival time.
D) Acute lymphocytic leukemias progress more slowly.

Question 7

A CBC,differential,and flow cytometry were performed on a patient with the following results (normal values): WBC = 8.0 th/uL (5.0-10.0 th/uL),diff = 90% lymphs (20-40%),CD3 = 5% (60-80%),CD5 = 95% (60-80%),CD19 = 95% (5-20%),CD10 = 0% (0%),surface Ig = pos (positive),and cytoplasmic Ig = neg (negative).What disease does this patient have?

A) B-cell acute lymphocytic leukemia
B) B-cell chronic leukemia
C) T-cell acute lymphocytic leukemia
D) T-cell chronic leukemia
E) AIDS

Question 8

What is the interpretation of the following patient results? (normal values)WBC = 7.0 th/uL (5.0-10.0 th/uL),with 89% blasts; CD3 = 10% (60-80%); CD5 = 9% (60-80%); CD10 = 89% (< 1%); CD4 = 6% (30-65%); CD20 = 0% (5-20%); CD34 = 94% (< 1%); CD8 = 3% (10-40%); kappa = 0% (3-15%); lambda = 0% (2-10%); CD19 = 90% (5-20%).

A) normal
B) B-cell acute leukemia
C) T-cell acute leukemia
D) B-cell chronic leukemia
E) T-cell chronic leukemia