Deck 13: Hypersensitivity

Question 1

Which isotype of immunoglobulin is involved in a type I hypersensitivity?

A) IgE
B) IgA
C) IgG
D) IgM

Answer 1

IgE

Question 2

Precipitation of immune complexes in small blood vessels under the skin that occurs when antigen is injected in an animal with large amounts of circulating antibody describes which of the following?

A) serum sickness
B) Arthus reaction
C) anaphylaxis
D) delayed hypersensitivity

Answer 2

Arthus reaction

Question 3

Type II hypersensitivity could involve all of the following EXCEPT:

A) IgE cross-linking on the mast cell or basophile
B) phagocytic cell degranulation and proteolytic enzyme activity
C) a kidney membrane antigen and specific antibody
D) natural killer cell activation and killing

Answer 3

IgE cross-linking on the mast cell or basophile

Question 4

Hypersensitivities to poison ivy (catechol)and nickel are:

A) mediated by IgG and IgM antibodies
B) immunodeficiency diseases
C) IgE responses to a hapten
D) macrophage responses to a hapten

Question 5

The principle difference between type II and type III hypersensitivity reactions is the:

A) isotype(s)of antibody involved
B) complement-mediated lysis of host cells
C) whether the antigen is cellular or soluble
D) involvement of helper T cells and macrophages

Question 6

A 5-year-old girl was rushed to the emergency department because she was having trouble breathing.She had been playing at the park when she fell down and her face and neck started to swell up.One of her friends thought that the girl might have been stung by a bee because a bee was flying around them and shortly before the girl fell to the ground,she had screamed.The girl had a large red bump on her cheek.This girl has:

A) Bruton's hypogammaglobulinemia
B) type I diabetes
C) type I hypersensitivity
D) type IV hypersensitivity

Question 7

Which of the following occurs in hemolytic disease of the newborn?

A) buildup of IgE on Mom's cells
B) Rh- Mom's exposure to Rh+ baby cells
C) Rh+ Mom's exposure to Rh- baby cells
D) baby must be Rh negative

Question 8

The radioimmunosorbent assay can be used for the diagnosis of which type of hypersensitivity?

A) IV
B) III
C) II
D) I

Question 9

Immune injury resulting from the localization of immune complexes in blood vessels and tissues describes which hypersensitivity reaction?

A) I
B) II
C) III
D) IV

Question 10

The normal activity of a type I hypersensitivity response is protection primarily against which of the following?

A) parasites
B) viruses
C) bacteria
D) fungi

Question 11

All of the following are involved in killing of large parasites EXCEPT:

A) degranulation of mast cells
B) action of eosinophil basic protein
C) production of IgE
D) activation of complement

Question 12

Anaphylaxis is characterized by all of the following EXCEPT:

A) IgE-coated mast cells
B) massive release of histamine
C) bronchoconstriction
D) circulating immune complexes

Question 13

Which of the following diseases is an example of a type II hypersensitivity?

A) anaphylaxis
B) myasthenia gravis
C) post-streptococcal glomerulonephritis
D) Bruton's agammaglobulinemia

Question 14

Anaphylactic reactions are mediated by:

A) mast cells
B) lymphocytes
C) macrophages
D) natural killer cells

Question 15

Reaction to poison ivy is which type of hypersensitivity?

A) I
B) II
C) III
D) IV

Question 16

A hypersensitivity reaction characterized by presence of IgG that reacts with soluble antigen best describes:

A) type III hypersensitivity
B) contact dermatitis
C) type II hypersensitivity
D) asthma

Question 17

Preformed mediators that are released during the activation phase of a type I hypersensitivity include which of the following?

A) histamine
B) cyclooxygenase
C) leukotriene
D) prostaglandin

Question 18

All of the hypersensitivity responses have which of the following in common?

A) involvement of antibody
B) asymptomatic sensitization phase
C) release of histamine
D) activation of macrophage

Question 19

An example of a type III hypersensitivity is:

A) myasthenia gravis
B) allergic rhinitis
C) contact sensitivity
D) rheumatoid arthritis

Question 20

All of the following hypersensitivity reactions involve activation of complement EXCEPT:

A) allergic reactions
B) hemolytic disease of the newborn
C) autoimmune hemolytic anemia
D) serum sickness

Question 21

Reasons for autoimmunity include all of the following EXCEPT:

A) antibody that cross-reacts with self-antigens
B) inheritance of certain MHC antigens
C) molecular mimicry
D) deletion of self-reactive lymphocytes during maturation

Question 22

An exaggerated reaction directed against an antigen that is harmless is called:

A) atopy
B) hypersensitivity
C) immune complex disease
D) passive cutaneous anaphylaxis

Question 23

To determine if a patient is allergic to peanuts,the best test to perform is:

A) RAST
B) RIST
C) serum protein electrophoresis
D) RID to measure IgG

Question 24

T cell-dependent hypersensitivity occurs:

A) 24 to 72 hours after exposure to the antigen
B) immediately after exposure to the antigen
C) 5 to 7 days after contact with antigen
D) 1 to 4 hours after contact with antigen

Question 25

Complement is responsible for tissue damage in which of the following reactions?

A) immediate hypersensitivity
B) type III hypersensitivity
C) delayed hypersensitivity
D) anaphylaxis

Question 26

All of the following are characteristic of cold autoimmune hemolytic anemia EXCEPT:

A) The antibody responsible is IgG.
B) It is usually in older patients.
C) The antibody reacts as an anti-I.
D) The reaction is only seen at cold temperatures.

Question 27

A positive DAT test might indicate which of the following?

A) autoimmune hemolytic anemia
B) allergic reaction
C) mismatch of a transplant
D) rheumatoid arthritis

Question 28

Anaphylaxis is characterized by which of the following?

A) degranulation of mast cells
B) production of IgG
C) T-cell mediators
D) all of the above

Question 29

Which of the following is a test for antibody to a specific allergen?

A) RAST
B) RPR
C) RIST
D) RID

Question 30

The immune mechanism involved in contact dermatitis is which of the following?

A) presence of circulating IgE
B) deposition of immune complexes
C) activation of complement
D) sensitization of cytotoxic T cells

Question 31

Complement is responsible for tissue damage in which of the following reactions?

A) immediate hypersensitivity
B) cytotoxic reactions
C) delayed hypersensitivity
D) anaphylaxis

Question 32

Cold autoimmune hemolytic anemia is an example of which type of hypersensitivity?

A) immediate
B) type II
C) type III
D) type IV

Question 33

In a direct antiglobulin test,what is being detected?

A) in vivo attachment of antibodies to red blood cells
B) allergic reaction
C) passive agglutination
D) naturally occurring antibodies

Question 34

Which is true of immediate hypersensitivity reactions?

A) Histamine is released from mast cells.
B) Antigen must bind to two IgE molecules.
C) Eosinophil chemotactic factor is released.
D) all of the above

Question 35

The PPD reaction to determine exposure to tuberculosis is based on which of the following?

A) formation of antigen-antibody complexes
B) an immediate hypersensitivity reaction
C) a sensitized T-cell response
D) a type II hypersensitivity reaction