Question 1

Which is true of immediate hypersensitivity reactions?

Accepted Answer

A)  Histamine is released from mast cells. 
B)  Antigen must bind to two IgE molecules. 
C)  Eosinophil chemotactic factor is released. 
D)  all of the above 
A)  Histamine is released from mast cells. 
B)  Antigen must bind to two IgE molecules. 
C)  Eosinophil chemotactic factor is released. 
D)  all of the above D

Question 2

Which isotype of immunoglobulin is involved in a type I hypersensitivity?

Accepted Answer

A)  IgE 
B)  IgA 
C)  IgG 
D)  IgM 
A)  IgE 
B)  IgA 
C)  IgG 
D)  IgM A

Question 3

The principle difference between type II and type III hypersensitivity reactions is the:

Accepted Answer

A)  isotype(s)of antibody involved 
B)  complement-mediated lysis of host cells 
C)  whether the antigen is cellular or soluble 
D)  involvement of helper T cells and macrophages 
A)  isotype(s)of antibody involved 
B)  complement-mediated lysis of host cells 
C)  whether the antigen is cellular or soluble 
D)  involvement of helper T cells and macrophages C

Question 4

An example of a type III hypersensitivity is:

Accepted Answer

A)  myasthenia gravis 
B)  allergic rhinitis 
C)  contact sensitivity 
D)  rheumatoid arthritis 
A)  myasthenia gravis 
B)  allergic rhinitis 
C)  contact sensitivity 
D)  rheumatoid arthritis

Question 5

The radioimmunosorbent assay can be used for the diagnosis of which type of hypersensitivity?

Accepted Answer

A)  IV 
B)  III 
C)  II 
D)  I 
A)  IV 
B)  III 
C)  II 
D)  I

Question 6

A 5-year-old girl was rushed to the emergency department because she was having trouble breathing.She had been playing at the park when she fell down and her face and neck started to swell up.One of her friends thought that the girl might have been stung by a bee because a bee was flying around them and shortly before the girl fell to the ground,she had screamed.The girl had a large red bump on her cheek.This girl has:

Accepted Answer

A)  Bruton's hypogammaglobulinemia 
B)  type I diabetes 
C)  type I hypersensitivity 
D)  type IV hypersensitivity 
A)  Bruton's hypogammaglobulinemia 
B)  type I diabetes 
C)  type I hypersensitivity 
D)  type IV hypersensitivity

Question 7

Anaphylaxis is characterized by all of the following EXCEPT:

Accepted Answer

A)  IgE-coated mast cells 
B)  massive release of histamine 
C)  bronchoconstriction 
D)  circulating immune complexes 
A)  IgE-coated mast cells 
B)  massive release of histamine 
C)  bronchoconstriction 
D)  circulating immune complexes

Question 8

Precipitation of immune complexes in small blood vessels under the skin that occurs when antigen is injected in an animal with large amounts of circulating antibody describes which of the following?

Accepted Answer

A)  serum sickness 
B)  Arthus reaction 
C)  anaphylaxis 
D)  delayed hypersensitivity 
A)  serum sickness 
B)  Arthus reaction 
C)  anaphylaxis 
D)  delayed hypersensitivity

Question 9

A hypersensitivity reaction characterized by presence of IgG that reacts with soluble antigen best describes:

Accepted Answer

A)  type III hypersensitivity 
B)  contact dermatitis 
C)  type II hypersensitivity 
D)  asthma 
A)  type III hypersensitivity 
B)  contact dermatitis 
C)  type II hypersensitivity 
D)  asthma

Question 10

Type II hypersensitivity could involve all of the following EXCEPT:

Accepted Answer

A)  IgE cross-linking on the mast cell or basophile 
B)  phagocytic cell degranulation and proteolytic enzyme activity 
C)  a kidney membrane antigen and specific antibody 
D)  natural killer cell activation and killing 
A)  IgE cross-linking on the mast cell or basophile 
B)  phagocytic cell degranulation and proteolytic enzyme activity 
C)  a kidney membrane antigen and specific antibody 
D)  natural killer cell activation and killing

Question 11

A positive DAT test might indicate which of the following?

Accepted Answer

A)  autoimmune hemolytic anemia 
B)  allergic reaction 
C)  mismatch of a transplant 
D)  rheumatoid arthritis 
A)  autoimmune hemolytic anemia 
B)  allergic reaction 
C)  mismatch of a transplant 
D)  rheumatoid arthritis

Question 12

Which of the following occurs in hemolytic disease of the newborn?

Accepted Answer

A)  buildup of IgE on Mom's cells 
B)  Rh- Mom's exposure to Rh+ baby cells 
C)  Rh+ Mom's exposure to Rh- baby cells 
D)  baby must be Rh negative 
A)  buildup of IgE on Mom's cells 
B)  Rh- Mom's exposure to Rh+ baby cells 
C)  Rh+ Mom's exposure to Rh- baby cells 
D)  baby must be Rh negative

Question 13

The immune mechanism involved in contact dermatitis is which of the following?

Accepted Answer

A)  presence of circulating IgE 
B)  deposition of immune complexes 
C)  activation of complement 
D)  sensitization of cytotoxic T cells 
A)  presence of circulating IgE 
B)  deposition of immune complexes 
C)  activation of complement 
D)  sensitization of cytotoxic T cells

Question 14

Reasons for autoimmunity include all of the following EXCEPT:

Accepted Answer

A)  antibody that cross-reacts with self-antigens 
B)  inheritance of certain MHC antigens 
C)  molecular mimicry 
D)  deletion of self-reactive lymphocytes during maturation 
A)  antibody that cross-reacts with self-antigens 
B)  inheritance of certain MHC antigens 
C)  molecular mimicry 
D)  deletion of self-reactive lymphocytes during maturation

Question 15

Complement is responsible for tissue damage in which of the following reactions?

Accepted Answer

A)  immediate hypersensitivity 
B)  cytotoxic reactions 
C)  delayed hypersensitivity 
D)  anaphylaxis 
A)  immediate hypersensitivity 
B)  cytotoxic reactions 
C)  delayed hypersensitivity 
D)  anaphylaxis

Question 16

Complement is responsible for tissue damage in which of the following reactions?

Accepted Answer

A)  immediate hypersensitivity 
B)  type III hypersensitivity 
C)  delayed hypersensitivity 
D)  anaphylaxis 
A)  immediate hypersensitivity 
B)  type III hypersensitivity 
C)  delayed hypersensitivity 
D)  anaphylaxis

Question 17

T cell-dependent hypersensitivity occurs:

Accepted Answer

A)  24 to 72 hours after exposure to the antigen 
B)  immediately after exposure to the antigen 
C)  5 to 7 days after contact with antigen 
D)  1 to 4 hours after contact with antigen 
A)  24 to 72 hours after exposure to the antigen 
B)  immediately after exposure to the antigen 
C)  5 to 7 days after contact with antigen 
D)  1 to 4 hours after contact with antigen

Question 18

Preformed mediators that are released during the activation phase of a type I hypersensitivity include which of the following?

Accepted Answer

A)  histamine 
B)  cyclooxygenase 
C)  leukotriene 
D)  prostaglandin 
A)  histamine 
B)  cyclooxygenase 
C)  leukotriene 
D)  prostaglandin

Question 19

Reaction to poison ivy is which type of hypersensitivity?

Accepted Answer

A)  I 
B)  II 
C)  III 
D)  IV 
A)  I 
B)  II 
C)  III 
D)  IV

Question 20

Which of the following diseases is an example of a type II hypersensitivity?

Accepted Answer

A)  anaphylaxis 
B)  myasthenia gravis 
C)  post-streptococcal glomerulonephritis 
D)  Bruton's agammaglobulinemia 
A)  anaphylaxis 
B)  myasthenia gravis 
C)  post-streptococcal glomerulonephritis 
D)  Bruton's agammaglobulinemia

Exam 13: Hypersensitivity

Which is true of immediate hypersensitivity reactions?

Which isotype of immunoglobulin is involved in a type I hypersensitivity?

The principle difference between type II and type III hypersensitivity reactions is the:

An example of a type III hypersensitivity is:

The radioimmunosorbent assay can be used for the diagnosis of which type of hypersensitivity?

Anaphylaxis is characterized by all of the following EXCEPT:

Precipitation of immune complexes in small blood vessels under the skin that occurs when antigen is injected in an animal with large amounts of circulating antibody describes which of the following?

A hypersensitivity reaction characterized by presence of IgG that reacts with soluble antigen best describes:

Type II hypersensitivity could involve all of the following EXCEPT:

A positive DAT test might indicate which of the following?

Which of the following occurs in hemolytic disease of the newborn?

The immune mechanism involved in contact dermatitis is which of the following?

Reasons for autoimmunity include all of the following EXCEPT:

Complement is responsible for tissue damage in which of the following reactions?

Complement is responsible for tissue damage in which of the following reactions?

T cell-dependent hypersensitivity occurs:

Preformed mediators that are released during the activation phase of a type I hypersensitivity include which of the following?

Reaction to poison ivy is which type of hypersensitivity?

Which of the following diseases is an example of a type II hypersensitivity?

Introduction and Natural Immunity

Lymphoid System

Nature of Antigens and Major Histocompatibility Complex

Antibody Structure and Function

Cytokines

Complement System

Safety and Specimen Preparation

Precipitation Reactions

Agglutination

Labeled Immunoassays

Molecular Techniques

Flow Cytometry and Laboratory Automation

Autoimmunity

Immunoproliferative Diseases

Immunodeficiency Disease

Transplantation Immunology

Tumor Immunology

Serologic and Molecular Detection of Bacterial Infections

Serologic and Molecular Detection of Bacterial Infections

Serology of Parasitic and Fungal Infections

Spirochete Diseases

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