A 56-Year-Old Woman Has Worked in a Photography Shop Developing

Multiple Choice

A 56-year-old woman has worked in a photography shop developing film for the past 20 years.She has a long history of shortness of breath and chronic cough,which have progressively become worse.Her FEV₁ and FVC values were reduced,but the FEV₁/FVC ratio was within the normal range.Her diffusion capacity,as measured with DLco,was low,at 15 mL/minute/mm Hg.Bronchoalveolar lavage and tissue biopsy were performed.The lavage sample revealed high numbers of abnormal-appearing macrophages and high numbers of dead macrophages. What type of pathologic process would you expect to find?

A) Peribronchial inflammation with eosinophils
B) Granuloma-like lesion in the terminal bronchioles with interstitial fibrosis and large foamy macrophages
C) Interstitial edema fluid accumulation with neutrophil infiltrate
D) Emphysematous lesion with large alveoli and minimum interstitial fibrosis