Because Calcium Channel Blockers Undergo Significant First-Pass Metabolism,which of the Following

Multiple Choice

Because calcium channel blockers undergo significant first-pass metabolism,which of the following responses would you expect to occur in a patient with cirrhosis who is taking a calcium channel blocker?

A) The drug is converted to active metabolites.
B) The drug's half-life is altered.
C) Titration of the dosage will be difficult.
D) No significant clinical difference will occur.