What Is the Principle Defect in Parkinson Disease

Multiple Choice

What is the principle defect in Parkinson disease?

A) There is a loss of neurons in the reticular activating system that secrete acetylcholine.
B) There is a demyelination of alpha motor neurons important for posture and balance.
C) Neurons of the substantia nigra degenerate and there is reduced delivery of dopamine to the basal ganglia.
D) Autoimmune destruction occurs in neurons in the motor regions of the cerebral cortex.
E) Damage to neurons of the cerebellum reduces the coordination of muscle movements.