Would a Change in the Nucleotide Sequence of DNA Change

Multiple Choice

Would a change in the nucleotide sequence of DNA change the structure of a protein?

A) One base equals one amino acid,so if there is a change in a base,it changes the amino acid,too.
B) A change in the DNA could lead to a change in the protein's amino acid sequence.This could lead to improper folding of the protein.
C) It wouldn't affect the protein;a change in the DNA sequence doesn't change the protein sequence.
D) A change in the DNA would only be caused by a change in the protein first.
E) None of the above.