Males Engrafted with HLA-Identical Bone Marrow from Their Sisters Develop

Multiple Choice

Males engrafted with HLA-identical bone marrow from their sisters develop graft-versus-host disease because _____.

A) T cells develop in the male thymus that are not tolerant to minor histocompatibility antigens expressed by the sister
B) mature T cells in the graft have specificity for male-specific minor histocompatibility antigens
C) there are differences between the sexes in how self proteins are modified post-translationally
D) NK-cell alloreactions occur
E) residual female hormones in the graft cause upregulation of HLA class I on male dendritic cells presenting minor histocompatibility antigens.