Charlene Cook,a 38-Year-Old Primigravida,is 35 Weeks Pregnant

Multiple Choice

Charlene Cook,a 38-year-old primigravida,is 35 weeks pregnant.Until recently she has had an uneventful pregnancy.Two weeks ago,her obstetrician noted lower-extremity edema,trace protein in her urine (10-20 mg/dl) ,and normal blood pressure (120/80 mmHg) .At today's appointment her blood pressure is elevated at 160/100 mmHg,she has marked proteinuria (3+; 300 mg/dl) ,worsening of ankle swelling,facial and hand swelling,and she mentions sudden onset of headache and visual disturbance.Charlene is admitted immediately to hospital and is diagnosed with pre-eclampsia.Within hours she is induced and gives birth to a healthy baby girl.In the context of uterine NK-cell function,which of the following is inconsistent with the cause of Charlene's pre-eclampsia?

A) There is inadequate extravillous trophoblast invasion of the spiral arteries or the uterus.
B) She has maternal homozygosity for the KIR A haplotype.
C) Uterine NK cells fail to secrete adequate amount of cytokines and growth factors needed to promote angiogenesis and remodeling of the maternal arteries.
D) The baby's father and mother are homozygous for the C1 epitope.
E) Insufficient activating signals were delivered to uterine NK cells.