Which of the Following Explains Why the First Baby Born

Multiple Choice

Which of the following explains why the first baby born to a RhD^- mother and a RhD⁺ father does not develop hemolytic disease of the newborn?

A) Fetal erythrocytes do not cross the placenta and therefore do not stimulate an antibody response.
B) The antibodies made by the RhD^- mother during the first pregnancy are predominantly IgM and have low affinity for the Rhesus antigen.
C) Maternal macrophages in the placenta bind to anti-Rhesus antibodies and prevent their transfer to the fetus.
D) Hemolytic disease of the newborn is a T-cell-mediated disease and maternal T cells do not cross the placenta during pregnancy.
E) The Rhesus antigen is not immunogenic and does not stimulate an antibody response.