If Viewing the Three-Dimensional Structure of a T-Cell Receptor from the Side,with

Multiple Choice

If viewing the three-dimensional structure of a T-cell receptor from the side,with the T-cell membrane at the bottom and the receptor pointing upwards,which of the following is inconsistent with experimental data?

A) The highly variable CDR loops are located across the top surface.
B) The membrane-proximal domains consist of C_α and C_β.
C) The portion that makes physical contact with the ligand comprises V_β and C_β,the domains farthest from the T-cell membrane.
D) The transmembrane regions span the plasma membrane of the T cell.
E) The cytoplasmic tails of the T-cell receptor α and β chains are very short.