Due to the Wobble Hypothesis,which Position in the Codon,if Changed

Multiple Choice

Due to the wobble hypothesis,which position in the codon,if changed to a different nucleotide,would be least likely to cause a change in the amino acid encoded?

A) second nucleotide of the codon
B) first nucleotide of the codon
C) third nucleotide of the codon
D) any nucleotide of the codon.
E) Either the first or second nucleotide of the codon.