What Is the Best Reason for the Relative Contraindication to Amide

Multiple Choice

What is the best reason for the relative contraindication to amide local anesthetics for patients with liver disease?

A) Amides are metabolized to ortho-toluidine.
B) Biotransformation of the amides occurs primarily in the liver.
C) Ester derivative drugs that are metabolized primarily in the lungs are available.
D) Cyanosis of the lips and mucous membranes may be observed.