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In the Disease Mononucleosis ("Mono"), the Spleen Enlarges Because of Increased

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In the disease mononucleosis ("mono"), the spleen enlarges because of increased macrophage activity. Common symptoms of this disease include pale complexion, premature muscle fatigue, weakness, and a lack of energy, sometimes to the point of not being able to get out of bed. What might cause these symptoms?

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A major function of the spleen is to des...

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