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Why Is an Amide Less Reactive to Nucleophilic Acyl Substitution

Question 28

Multiple Choice

Why is an amide less reactive to nucleophilic acyl substitution than an acid chloride?


A) Nitrogen is a better leaving group.
B) Chloride is a better leaving group.
C) Nitrogen donates more electron density into the carbonyl.
D) The amide anion is less basic.

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