Aerobic Respiration Involves the Transfer of Many Electrons from Glucose

Multiple Choice

Aerobic respiration involves the transfer of many electrons from glucose to electron carriers such as NAD⁺ over a series of multiple steps.Ultimately though,it is the reaction of glucose with oxygen to generate carbon dioxide,water and energy.Why doesn't glucose react directly with oxygen in cells?

A) Oxygen cannot accept electrons,and thus an electron carrier like NAD⁺ is needed.
B) Oxygen and glucose are localized in different subcellular compartments.
C) The direct reaction of oxygen with glucose would be extremely destructive to cells.
D) The reaction of oxygen with glucose is not spontaneous.