Essay
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Human mitochondrial DNA is transmitted exclusively by ____1_____. As well as transmitting chromosomes ???to the oocyte, sperm also transmit _____2____ but they are selectively ___3____ in the early embryo. Because mtDNA replication is independent of the cell cycle and there are many mtDNA molecules per cell, a population of mutant mtDNA molecules can co-exist in a cell with a population of normal mtDNA molecules, a state known as _____4_____. Because mtDNA replication is ____5____ and because ____6____ expansion of mutant DNAs is variable, the proportion of mutant to normal mtDNAs in a cell can ___7____ significantly between cells in the same individual.
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