In Terms of Its Contribution to Pathogenesis Which of the Following

Multiple Choice

In terms of its contribution to pathogenesis which of the following mutant proteins is the odd one out, and why is it the exception?

A) $\beta$ -globin carrying the p.Glu6Val substitution .
B) PI*Z and PI*E mutant $\alpha$ ₁-antitrypsins
C) mutant CFTR protein with the common p.Phe508del deletion.
D) mutant prion proteins.