With Respect to Epimutations, Which, If Any, of the Following

Multiple Choice

With respect to epimutations, which, if any, of the following statements, is false, from a practical viewpoint?

A) The term epimutation means an unexpected change in chromatin conformation, causing a gene to be expressed in an abnormal way that is not related to its base sequence.
B) A primary epimutation is a change in chromatin confirmation that is not related directly to any change in the base sequence.
C) A secondary epimutation arises from a standard mutation that results in a profound change of expression in a gene that regulates chromatin conformation.
D) A "chromatin disease" is a disorder that is consistently caused by a primary epimutation.