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Essay

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In cell-based DNA cloning, a DNA population of interest (which consists of very long DNA fragments) needs to be cleaved by a _____1_____ ____2______ into manageably short DNA pieces that can be transported more easily into cells. The resulting DNA fragments are joined by a ___3____ ____4______ to a ____5____ DNA, resulting in the formation of a ____6____ ___3___. The ___5___ carries a replication origin that allows it, and the ____6____ ___3____ , to replicate within a suitable host dell, usually some type of ____7____ or ____8____ cell.