A Mutation of Lys₂₂₉ in Aldolase Leads to a Loss

Multiple Choice

A mutation of Lys₂₂₉ in aldolase leads to a loss of enzyme activity.This is most likely because the

A) active site can no longer exclude water.
B) active site can no longer include water.
C) enzyme can no longer hold the intermediate in the correct orientation for catalysis.
D) product will remain bound to the enzyme active site.