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The Glutamate Side Chain in the Active Site of HMG-CoA

Question 12

Multiple Choice

The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after


A) the mevalonate binds to the active site.
B) the hydride from the second NADPH attacks the carbonyl center of the aldehyde.
C) a conformational change triggers the exchange of NADP+ for NADPH.
D) CoA is reduced to CoA-SH.

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