Typical Folded Proteins Have a Stability Ranging from 7 to 15

Essay

Typical folded proteins have a stability ranging from 7 to 15 kcal/mole at 37°C.Stability is a measure of the equilibrium between the folded (F) and unfolded (U) forms of the protein.For a protein with a stability of 7.1 kcal/mole, calculate the fraction of protein molecules that would be unfolded at equilibrium at 37°C.The equilibrium constant (K_eq) is related to the standard free energy (ΔG°) by the equation K_eq = 10^{−ΔG°/1.42}. $F \rightleftharpoons U$
$K _ { e q } = \frac { [ U ] } { [ F ] }$
Figure 4-56