Initiator Proteins Bind to Replication Origins and Disrupt Hydrogen Bonds

Multiple Choice

Initiator proteins bind to replication origins and disrupt hydrogen bonds between the two DNA strands being copied.Which of the factors below does not contribute to the relative ease of strand separation by initiator proteins?

A) replication origins are rich in A-T base pairs
B) the reaction can occur at room temperature
C) they only separate a few base pairs at a time
D) once opened, other proteins of the DNA replication machinery bind to the origin