The Problem Below Relates to the Synthesis of Several Intermediates

Essay

The problem below relates to the synthesis of several intermediates in the citric acid cycle, which is essential in the production of ATP through aerobic respiration. A set of experimental results relating the growth (+) of Neurospora on several media is given in the table. Based on the information provided, present the biochemical pathway for the substances oxaloacetate, fumarate, malate, and succinate, and the locations of the metabolic blocks produced by the various strains. $$\begin{array} { l c c c c c } \text { Strain } & \text { MM } & \begin{array} { c } \text { MM } \\\text { + oxaloacetate }\end{array} & \begin{array} { c } \text { MMedium } \\\text { Mumarate }\end{array} & \begin{array} { c } \text { MM } \\+ \text { malate }\end{array} & \begin{array} { c } \text { MM } \\+ \text { succinate }\end{array} \\\hline 162 & - & + & - & + & - \\136 & - & + & - & - & - \\141 & - & + & + & + & -\end{array}$$