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Assume That a Series of Compounds Has Been Discovered in Neurospora.Compounds

Question 23

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Assume that a series of compounds has been discovered in Neurospora.Compounds A-F appear to be intermediates in a biochemical pathway.Conversion of one intermediate to the next is controlled by enzymes that are encoded by genes.Several mutations in these genes have been identified and Neurospora strains 1-4 each contain a single mutation.Strains 1-4 are grown on minimal media supplemented with one of the compounds A-F.The ability of each strain to grow when supplemented with different compounds is shown in the table (+ = growth; o = no growth) . Which biochemical pathway fits the data presented?
Media supplement
 strain  A  B  C  D  E  F 1ooo+++2oooo++3oooo+o4oo++++\begin{array} { | l | l | l | l | l | l | l | } \hline \text { strain } & \text { A } & \text { B } & \text { C } & \text { D } & \text { E } & \text { F } \\\hline 1 & o & o & o & + & + & + \\\hline 2 & o & o & o & o & + & + \\\hline 3 & o & o & o & o & + & o \\\hline 4 & o & o & + & + & + & + \\\hline\end{array}


A) A ? B ? C ? D ? E ? F
B) A ? B ? C ? F ? D ? E
C) F ? B ? C ? D ? A ? E
D) A ? B ? C ? D ? F ? E
E) A ? B ? F ? E ? C ? D

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