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Homologous Recombination Occurs in a Heterozygote in Which Alleles D

Question 53

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Homologous recombination occurs in a heterozygote in which alleles D and d differ by a single base pair.The D allele has a G at one position, whereas the d allele has a C at the same position.If branch migration causes heteroduplex formation across this position, what is the expected outcome?


A) Both D and d alleles will remain unchanged because G can base pair with C.
B) Mismatch repair will identify an abnormal G-G base pair and may convert the D allele to a d allele.
C) Mismatch repair will identify an abnormal C-G base pair and will ensure that the cell has two copies of each allele.
D) Mismatches will cause the Holliday junction to be unstable and to resolve by the noncrossover pathway.

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